关于电子舌在开发含苦味成分的口服药物配方中的性能鉴定的批判性观点

Denise Steiner, Alexander Meyer, L. I. Immohr, M. Pein-Hackelbusch
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引用次数: 0

摘要

在这篇综述中,我们旨在强调电子舌(e-tongues)在药物开发中的优势、挑战和局限性。因此,作者对电子舌在评估含有苦味活性药物成分的口服制剂方面的性能进行了严格的评估。因此,作者首先使用 "电子"、"舌"、"苦味 "和 "药物 "等关键词在科学网进行了文献检索。作者回顾了过去十年的出版物,并在必要时查阅了更多文献,从而得以讨论电子舌是否以及如何达到预期效果,是否有潜力成为药物开发的标准工具。其中特别强调了电子舌应该满足的期望。此外,作者还简要介绍了所使用的电子舌技术。研究发现了可靠的规程,可(i)从分析角度确保电子舌仪器的合格性能,(ii)进行适当的掩味评估,以及(iii)在某些情况下进行苦味评估。
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Critical View on the Qualification of Electronic Tongues Regarding Their Performance in the Development of Peroral Drug Formulations with Bitter Ingredients
In this review, we aim to highlight the advantages, challenges, and limitations of electronic tongues (e-tongues) in pharmaceutical drug development. The authors, therefore, critically evaluated the performance of e-tongues regarding their qualification to assess peroral formulations containing bitter active pharmaceutical ingredients. A literature search using the keywords ‘electronic’, ‘tongue’, ‘bitter’, and ‘drug’ in a Web of Science search was therefore initially conducted. Reviewing the publications of the past decade, and further literature where necessary, allowed the authors to discuss whether and how e-tongues perform as expected and whether they have the potential to become a standard tool in drug development. Specifically highlighted are the expectations an e-tongue should meet. Further, a brief insight into the technologies of the utilized e-tongues is given. Reliable protocols were found that enable (i) the qualified performance of e-tongue instruments from an analytical perspective, (ii) proper taste-masking assessments, and (iii) under certain circumstances, the evaluation of bitterness.
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