COVID-19 大流行对动脉高血压和冠心病入院率的影响:德国数据库研究

B. Sasko, Marios Matiakis, F. Seibert, N. Pagonas, Hans-Jörg Hippe, N. Babel, Christian Ukena, Timm H. Westhoff
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摘要

在 SARS-CoV-2 大流行期间,人们推测该病毒可能与心血管风险的持续增加有关。本研究比较了大流行前后高血压和冠状动脉疾病的入院率。在两个不同时期(大流行前的 2019 年 6 月 1 日与大流行后的 2023 年 6 月 1 日),对德国一个城市地区的 57795 例入院病例进行了系统性多中心回顾性队列分析。从医院数据系统中提取了动脉高血压、慢性冠状动脉综合征、不稳定型心绞痛和急性心肌梗死的入院信息。与大流行前相比,动脉高血压(516 对 483,-6.8%,P = 0.07)和心肌梗塞(487 对 349,-23.8%,P = 0.07)的住院人数没有增加。349,-23.8%,p<0.001),但以胸痛为主要症状的住院患者总数有所增加(慢性冠状动脉综合征:759 对 943,+24.2%,p<0.001;不稳定型心绞痛:270 对 451,+67.0%,p<0.001)。与此同时,进行冠状动脉造影术的人数增加了,但接受经皮介入治疗的患者减少了。本项多中心队列研究没有发现大流行结束后动脉高血压或冠状动脉疾病住院人数增加的证据。然而,要证实我们的研究结果,还需要进行样本量更大的进一步研究。
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Impact of the COVID-19 pandemic on hospital admission rates for arterial hypertension and coronary heart disease: a German database study
During the SARS-CoV-2 pandemic it was speculated that the virus might be associated with a persistent increase of cardiovascular risk. The present study compares pre- and post-pandemic hospital admission rates for hypertension and coronary artery disease.Systematic multicentric retrospective cohort analysis of 57.795 hospital admissions in an urban region in Germany during two different periods (pre-pandemic 01–06/2019 vs. post-pandemic era 01–06/2023). Information on hospital admissions for arterial hypertension, chronic coronary syndrome, unstable angina pectoris and acute myocardial infarction were extracted from the hospitals data systems. Additionally, six comorbidities and performed coronary interventions were monitored.Compared to the pre-pandemic era, there was no increase in hospitalizations for arterial hypertension (516 vs. 483, −6.8%, p = 0.07) or myocardial infarction (487 vs. 349, −23.8%, p < 0.001), but the total number of patient admissions with chest pain as the presenting symptom increased (chronic coronary syndrome: 759 vs. 943, +24.2%, p < 0.001; unstable angina pectoris: 270 vs. 451, +67.0%, p < 0.001). At the same time, the number of performed coronary angiographies increased, but less patients underwent percutaneous interventions. Patients admitted with chest pain in the post-pandemic era were in general healthier with less comorbidities.The present multicenter cohort study found no evidence for an increase in hospitalizations for arterial hypertension or coronary artery disease after the end of the pandemic. However, further studies with larger sample sizes are needed to confirm our results.
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