胆碱代谢在非酒精性脂肪肝和癌症中的作用和机制

Frontiers in Bioscience-Landmark Pub Date : 2024-05-11 DOI:10.31083/j.fbl2905182

Xin Chen, Wenying Qiu, Xuqian Ma, Linli Ren, Mingqian Feng, Sheng Hu, Chang Xue, Runzhi Chen

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摘要

胆碱参与三大代谢途径：氧化、磷酸化和乙酰化。通过氧化，胆碱转化为甜菜碱，促进甲基代谢和表观遗传调节。通过磷酸化，胆碱参与磷脂代谢，是磷脂酰胆碱、磷脂酰胆碱、甘油磷脂酰胆碱的前体。

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Roles and Mechanisms of Choline Metabolism in Nonalcoholic Fatty Liver Disease and Cancers

Choline participates in three major metabolic pathways: oxidation, phosphorylation, and acetylation. Through oxidation, choline is converted to betaine and contributes to methyl metabolism and epigenetic regulation. Through phosphorylation, choline participates in phospholipid metabolism, and serves as the precursor of phosphocholine, phosphatidylcholine, glycerophosphocholine

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Frontiers in Bioscience-Landmark

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