Meng-Hung Shih, Tai‐Lung Cha, Sheng‐Tang Wu, E. Meng, C. Tsao, C. Kao, Chin‐Li Chen, Yu-Ching Juho, Hui-Kung Ting, Guang‐Huan Sun, Sun‐Yran Chang, Dah-Shyong Yu, Ming‐Hsin Yang
{"title":"循环肿瘤细胞中的 Plastin 3 表达可预测前列腺癌患者的癌症状况","authors":"Meng-Hung Shih, Tai‐Lung Cha, Sheng‐Tang Wu, E. Meng, C. Tsao, C. Kao, Chin‐Li Chen, Yu-Ching Juho, Hui-Kung Ting, Guang‐Huan Sun, Sun‐Yran Chang, Dah-Shyong Yu, Ming‐Hsin Yang","doi":"10.1097/fs9.0000000000000134","DOIUrl":null,"url":null,"abstract":"\n \n \n To identify the role of plastin3 (PLS3) expression in circulating tumor cells (CTCs) of early stage prostate cancer (PCa).\n \n \n \n CTCs were collected from 23 prostate cancer patients based on cell surface markers targeting prostate cancer by V-BioChip. Condition of Plastin3 expression and correlations to the prostate cancer were also analyzed.\n \n \n \n Of the 23 patients with prostate cancer, total CTCs (CK+ or PLS3+) were found in 11 patients and PLS3+ CTCs were detected in 10 patients. When the cohort was stratified by risk group, 90% of the high-risk patients were found to have PLS3+ circulating tumor cells (9/10 patients). However, only 15.4% of low/intermediate-risk patients had PLS3+ circulating tumor cells (2/13 patients). The number of PLS3+ CTCs was higher in the high-risk group.\n \n \n \n The expression of PLS3 in CTCs is associated with prostate cancer risk. Further study of PLS3+ CTCs for prognosis prediction is required for clinical application in prostate cancer patients.\n","PeriodicalId":12390,"journal":{"name":"Formosan Journal of Surgery","volume":null,"pages":null},"PeriodicalIF":0.2000,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Plastin 3 Expression in Circulating Tumor Cells as a Predictor of Cancer Status in Patients with Prostate Cancer\",\"authors\":\"Meng-Hung Shih, Tai‐Lung Cha, Sheng‐Tang Wu, E. Meng, C. Tsao, C. Kao, Chin‐Li Chen, Yu-Ching Juho, Hui-Kung Ting, Guang‐Huan Sun, Sun‐Yran Chang, Dah-Shyong Yu, Ming‐Hsin Yang\",\"doi\":\"10.1097/fs9.0000000000000134\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n \\n \\n To identify the role of plastin3 (PLS3) expression in circulating tumor cells (CTCs) of early stage prostate cancer (PCa).\\n \\n \\n \\n CTCs were collected from 23 prostate cancer patients based on cell surface markers targeting prostate cancer by V-BioChip. Condition of Plastin3 expression and correlations to the prostate cancer were also analyzed.\\n \\n \\n \\n Of the 23 patients with prostate cancer, total CTCs (CK+ or PLS3+) were found in 11 patients and PLS3+ CTCs were detected in 10 patients. When the cohort was stratified by risk group, 90% of the high-risk patients were found to have PLS3+ circulating tumor cells (9/10 patients). However, only 15.4% of low/intermediate-risk patients had PLS3+ circulating tumor cells (2/13 patients). The number of PLS3+ CTCs was higher in the high-risk group.\\n \\n \\n \\n The expression of PLS3 in CTCs is associated with prostate cancer risk. Further study of PLS3+ CTCs for prognosis prediction is required for clinical application in prostate cancer patients.\\n\",\"PeriodicalId\":12390,\"journal\":{\"name\":\"Formosan Journal of Surgery\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2024-05-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Formosan Journal of Surgery\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1097/fs9.0000000000000134\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Formosan Journal of Surgery","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/fs9.0000000000000134","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SURGERY","Score":null,"Total":0}
Plastin 3 Expression in Circulating Tumor Cells as a Predictor of Cancer Status in Patients with Prostate Cancer
To identify the role of plastin3 (PLS3) expression in circulating tumor cells (CTCs) of early stage prostate cancer (PCa).
CTCs were collected from 23 prostate cancer patients based on cell surface markers targeting prostate cancer by V-BioChip. Condition of Plastin3 expression and correlations to the prostate cancer were also analyzed.
Of the 23 patients with prostate cancer, total CTCs (CK+ or PLS3+) were found in 11 patients and PLS3+ CTCs were detected in 10 patients. When the cohort was stratified by risk group, 90% of the high-risk patients were found to have PLS3+ circulating tumor cells (9/10 patients). However, only 15.4% of low/intermediate-risk patients had PLS3+ circulating tumor cells (2/13 patients). The number of PLS3+ CTCs was higher in the high-risk group.
The expression of PLS3 in CTCs is associated with prostate cancer risk. Further study of PLS3+ CTCs for prognosis prediction is required for clinical application in prostate cancer patients.
期刊介绍：
Formosan Journal of Surgery, a publication of Taiwan Surgical Association, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.e-fjs.org. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.
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