复合抗氧化疗法对女性盆腔静脉曲张的临床疗效:前瞻性非随机对照研究

Q3 Medicine Gynecology Pub Date : 2024-05-09 DOI:10.26442/20795696.2024.1.202556
D. A. Stupin, L. I. Kolesnikova, A. Semendyaev, M. Darenskaya, Daria V. Tukhieva, Ekaterina S. Bystrova, Ksenia V. Kuryshova, A. I. Gus
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When assessing the parameters of the lipoperoxidation system (antioxidant protection) in group 1 during CAT combined with standard venotropic therapy, there was a statistically significant decrease in the levels of lipid hydroperoxides (p0.0001), diene conjugates (p=0.001), malonic dialdehyde (p0.0001), an increase in the levels of catalase (p0.0001), superoxide dismutase (p0.0001), glutathione peroxidase (p0.0001), glutathione reductase (p0.0001), glutathione-S-transferase (p=0.002) and the reduced glutathione content (p=0.032) compared to levels before treatment. The above group showed a decrease in the diameter of the pelvic varicose veins: internal iliac (p0.001), ovarian (p0.0001) and arcuate (p0.001), an increase in their blood flow velocity (p=0.003, 0.041, and 0.040, respectively), a decrease in the duration of retrograde flow to 0.3 cm. 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引用次数: 0

摘要

目的:评估复合抗氧化疗法(CAT)治疗盆腔静脉曲张患者的临床疗效。评估复合抗氧化疗法(CAT)治疗盆腔静脉曲张(PVV)患者的临床疗效。材料和方法。将盆腔静脉曲张患者(n=150)分为 1 组和 2 组,每组 75 人;两组具有可比性。两组的治疗均包括使用一种静脉促进剂进行标准治疗(60 天)。第 1 组患者还接受了为期 30 天(1 个疗程)的 CAT 治疗,共 3 个疗程,每疗程间隔 2 个月。结果在 CAT 联合标准静脉治疗期间评估第 1 组患者的脂质过氧化系统(抗氧化保护)参数时,脂质氢过氧化物(P0.0001)、二烯共轭物(P=0.001)、丙二醛(P0.0001),过氧化氢酶(p0.0001)、超氧化物歧化酶(p0.0001)、谷胱甘肽过氧化物酶(p0.0001)、谷胱甘肽还原酶(p0.0001)、谷胱甘肽-S-转移酶(p=0.002)和还原型谷胱甘肽含量(p=0.032)与治疗前水平相比均有所增加。上述治疗组患者的盆腔静脉曲张:髂内静脉(p0.001)、卵巢静脉(p0.0001)和弓形静脉(p0.001)的直径均有所下降,血流速度有所提高(分别为 p=0.003、0.041 和 0.040),逆流时间缩短至 0.3 厘米。盆腔疼痛(p0.0001)、痛经(p=0.024)、排便困难(p=0.037)、月经不调频率(p=0.031)均有所减少,生活质量(p=0.047)、怀孕率(p=0.013)、活产数量(p=0.004)和缓解持续时间(p=0.047)均有所改善。结论联合使用抗氧化剂超氧化物歧化酶250毫克,每天2次;乙酰-谷胱甘肽100毫克,每天2次;虾青素400毫克,每天1次,连续使用30天,分3个疗程,每疗程间隔2个月,再结合静脉注射疗法,可显著改善PVV患者的治疗效果。
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Clinical efficacy of complex antioxidant therapy for pelvic varicose veins in women: A prospective non-randomized controlled study
Aim. To evaluate the clinical efficacy of complex antioxidant therapy (CAT) in the treatment of patients with pelvic varicose veins (PVV). Materials and methods. Patients with PVV (n=150) were divided into groups 1 and 2 of 75 subjects; the groups were comparable. Treatment in both groups included standard therapy with one of the venotropic agents (60 days). Patients of group 1 additionally received CAT for 30 days (1 course), in total 3 courses with 2-month intervals. Results. When assessing the parameters of the lipoperoxidation system (antioxidant protection) in group 1 during CAT combined with standard venotropic therapy, there was a statistically significant decrease in the levels of lipid hydroperoxides (p0.0001), diene conjugates (p=0.001), malonic dialdehyde (p0.0001), an increase in the levels of catalase (p0.0001), superoxide dismutase (p0.0001), glutathione peroxidase (p0.0001), glutathione reductase (p0.0001), glutathione-S-transferase (p=0.002) and the reduced glutathione content (p=0.032) compared to levels before treatment. The above group showed a decrease in the diameter of the pelvic varicose veins: internal iliac (p0.001), ovarian (p0.0001) and arcuate (p0.001), an increase in their blood flow velocity (p=0.003, 0.041, and 0.040, respectively), a decrease in the duration of retrograde flow to 0.3 cm. There was a decrease in pelvic pain (p0.0001), dysmenorrhea (p=0.024), dyspareunia (p=0.037), the frequency of irregular menstruation (p=0.031), an improvement in quality of life (p=0.047), pregnancy rate (p=0.013), the number of live births (p=0.004), and the duration of remission (p=0.047). Conclusion. The use of a combination of antioxidants superoxide dismutase 250 mg 2 times a day, acetyl-glutathione at 100 mg 2 times a day, and astaxanthin 400 mg/day for 30 days in 3 courses with 2-month intervals combined with venotropic therapy can significantly improve the treatment outcomes of patients with PVV.
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来源期刊
Gynecology
Gynecology Medicine-Obstetrics and Gynecology
CiteScore
0.70
自引率
0.00%
发文量
52
审稿时长
8 weeks
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