Yongxiang Hu, Yu Zhou, Guohu Luo, Dege Li, Minni Qu
{"title":"将飞秒激光诱导的纳米粒子植入柔性基底,实现灵敏、可重复使用的微流体 SERS 检测","authors":"Yongxiang Hu, Yu Zhou, Guohu Luo, Dege Li, Minni Qu","doi":"10.1088/2631-7990/ad48e9","DOIUrl":null,"url":null,"abstract":"\n Surface-enhanced Raman spectroscopy (SERS) microfluidic system, which enables rapid detection of chemical and biological analytes, offers an effective platform to monitor various food contaminants and disease diagnoses. The efficacy of SERS microfluidic systems is greatly dependent on the sensitivity and reusability of SERS detection substrates to ensure repeated use for prolonged periods. This study proposed a novel process of femtosecond laser nanoparticle array (NPA) implantation to achieve homogeneous forward transfer of gold NPA on a flexible polymer film and accurately integrated it within microfluidic chips for SERS detection. The implanted Au-NPA strips show a remarkable electromagnetic field enhancement with the factor of 9×108 during SERS detection of malachite green (MG) solution, achieving a detection limit lower than 10 ppt, far better than most laser-prepared SERS substrates. Furthermore, Au-NPA strips show excellent reusability after several physical and chemical cleaning, because of the robust embedment of laser-implanted NPA in flexible substrates. To demonstrate the performance of Au-NPA, a SERS microfluidic system is built to monitor the online oxidation reaction between MG/NaClO reactants, which helps infer the reaction path. The proposed method of nanoparticle implantation is more effective than the direct laser structuring technique. It provides better performance for SERS detection, robustness of detection, and substrate flexibility and has a wider range of applications for microfluidic systems without any negative impact.","PeriodicalId":52353,"journal":{"name":"International Journal of Extreme Manufacturing","volume":null,"pages":null},"PeriodicalIF":16.1000,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Femtosecond Laser-induced Nanoparticle Implantation into Flexible Substrate for Sensitive and Reusable Microfluidics SERS Detection\",\"authors\":\"Yongxiang Hu, Yu Zhou, Guohu Luo, Dege Li, Minni Qu\",\"doi\":\"10.1088/2631-7990/ad48e9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n Surface-enhanced Raman spectroscopy (SERS) microfluidic system, which enables rapid detection of chemical and biological analytes, offers an effective platform to monitor various food contaminants and disease diagnoses. The efficacy of SERS microfluidic systems is greatly dependent on the sensitivity and reusability of SERS detection substrates to ensure repeated use for prolonged periods. This study proposed a novel process of femtosecond laser nanoparticle array (NPA) implantation to achieve homogeneous forward transfer of gold NPA on a flexible polymer film and accurately integrated it within microfluidic chips for SERS detection. The implanted Au-NPA strips show a remarkable electromagnetic field enhancement with the factor of 9×108 during SERS detection of malachite green (MG) solution, achieving a detection limit lower than 10 ppt, far better than most laser-prepared SERS substrates. Furthermore, Au-NPA strips show excellent reusability after several physical and chemical cleaning, because of the robust embedment of laser-implanted NPA in flexible substrates. To demonstrate the performance of Au-NPA, a SERS microfluidic system is built to monitor the online oxidation reaction between MG/NaClO reactants, which helps infer the reaction path. The proposed method of nanoparticle implantation is more effective than the direct laser structuring technique. It provides better performance for SERS detection, robustness of detection, and substrate flexibility and has a wider range of applications for microfluidic systems without any negative impact.\",\"PeriodicalId\":52353,\"journal\":{\"name\":\"International Journal of Extreme Manufacturing\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.1000,\"publicationDate\":\"2024-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Extreme Manufacturing\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/2631-7990/ad48e9\",\"RegionNum\":1,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MANUFACTURING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Extreme Manufacturing","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/2631-7990/ad48e9","RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MANUFACTURING","Score":null,"Total":0}
Femtosecond Laser-induced Nanoparticle Implantation into Flexible Substrate for Sensitive and Reusable Microfluidics SERS Detection
Surface-enhanced Raman spectroscopy (SERS) microfluidic system, which enables rapid detection of chemical and biological analytes, offers an effective platform to monitor various food contaminants and disease diagnoses. The efficacy of SERS microfluidic systems is greatly dependent on the sensitivity and reusability of SERS detection substrates to ensure repeated use for prolonged periods. This study proposed a novel process of femtosecond laser nanoparticle array (NPA) implantation to achieve homogeneous forward transfer of gold NPA on a flexible polymer film and accurately integrated it within microfluidic chips for SERS detection. The implanted Au-NPA strips show a remarkable electromagnetic field enhancement with the factor of 9×108 during SERS detection of malachite green (MG) solution, achieving a detection limit lower than 10 ppt, far better than most laser-prepared SERS substrates. Furthermore, Au-NPA strips show excellent reusability after several physical and chemical cleaning, because of the robust embedment of laser-implanted NPA in flexible substrates. To demonstrate the performance of Au-NPA, a SERS microfluidic system is built to monitor the online oxidation reaction between MG/NaClO reactants, which helps infer the reaction path. The proposed method of nanoparticle implantation is more effective than the direct laser structuring technique. It provides better performance for SERS detection, robustness of detection, and substrate flexibility and has a wider range of applications for microfluidic systems without any negative impact.
期刊介绍:
The International Journal of Extreme Manufacturing (IJEM) focuses on publishing original articles and reviews related to the science and technology of manufacturing functional devices and systems with extreme dimensions and/or extreme functionalities. The journal covers a wide range of topics, from fundamental science to cutting-edge technologies that push the boundaries of currently known theories, methods, scales, environments, and performance. Extreme manufacturing encompasses various aspects such as manufacturing with extremely high energy density, ultrahigh precision, extremely small spatial and temporal scales, extremely intensive fields, and giant systems with extreme complexity and several factors. It encompasses multiple disciplines, including machinery, materials, optics, physics, chemistry, mechanics, and mathematics. The journal is interested in theories, processes, metrology, characterization, equipment, conditions, and system integration in extreme manufacturing. Additionally, it covers materials, structures, and devices with extreme functionalities.