长期使用质子泵抑制剂的副作用:关注泌尿系统

D. Trukhan, I. Viktorova
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引用次数: 0

摘要

质子泵抑制剂(PPI)是治疗胃酸相关疾病的最有效药物。近几十年来,PPIs 的使用量成倍增加。长期以来,PPIs 被认为是短期和长期使用都完全安全的药物。然而,现代临床指南指出,在长期大剂量处方 PPIs 时,应考虑到副作用的可能性。近年来,国外发表了多篇综述,探讨了 PPI 与多种疾病/病症之间的关联。我们在 PubMed 和 Scopus 信息数据库中搜索了有关 PPI 使用安全性的出版物,包括截至 2024 年 1 月 30 日的资料来源。在这篇综述中,我们研究了长期服用 PPI 对泌尿系统的影响。本综述表明,长期使用 PPIs 可能会导致泌尿系统发生变化,并增加患肾炎、急性间质性肾炎、急性肾损伤、慢性肾病、终末期肾衰竭的风险。
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Side effects of proton pump inhibitors with long-term use: focus on the urinary system
Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the associations between PPIs and a number of diseases/conditions. We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to January 30, 2024. In this review, we examined the effect of long-term use of PPIs on the urinary system. This review demonstrates possible changes in the urinary system and an increased risk of developing nephrolithiasis, acute interstitial nephritis, acute kidney injury, chronic kidney disease, end-stage renal failure with long-term use of PPIs, which should certainly be taken into account when prescribing them for a long period, especially in patients with comorbid pathology.
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