美贝维林缓释胶囊对功能性胃肠病患者肠道运动功能的影响

M. A. Butov, M. Msakni, V. M. Butova, N. A. Sudakova, I. Y. Vornacheva, L. I. Karpova
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摘要

研究目的评估使用 PPI 奥美拉唑和促肌解痉药盐酸甲贝维林缓释胶囊(Meberin ML. Micro Labs Limited, India)联合治疗 FGID 重叠综合征--胃食管反流病(GERD)、功能性消化不良(FD)和肠易激综合征(IBS)对 FGID 重叠综合征--胃食管反流病、功能性消化不良和肠易激综合征--患者的临床表现和胃肠道运动排空功能的临床疗效、印度 Micro Labs 有限公司)对伴有胃食管反流病、伴有胃分泌亢进的 FD 和肠易激综合征(IBS)重叠综合征的 FGID 患者的临床表现和胃肠道运动排空功能的影响。材料和方法我们对27名患有胃食管反流病、FD伴胃酸盐分泌过多和肠易激综合征重叠综合征的FGID患者进行了检查。经证实,在 97% 的病例中,使用这些药物进行为期两周的联合治疗可消除综合征的临床症状,改善患者的生活质量,使肠道运动和胃肠道肌电活动恢复正常。
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The effect of mebeverine in extended-release capsules on intestinal motor function in patients with functional gastrointestinal pathology
Purpose of the study. Evaluation of the clinical effectiveness of combination therapy for FGID with overlap syndrome – gastroesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) using the PPI omeprazole and the myotropic antispasmodic mebeverine hydrochloride in extended-release capsules (Meberin ML, Micro Labs Limited, India) on clinical manifestations and motor-evacuation function of the gastrointestinal tract in patients with FGID with overlap syndrome – GERD, FD with gastric hypersecretion and IBS.Materials and methods. We examined 27 patients with FGID with overlap syndrome of GERD, FD with gastric hypersecretion of hydrochloric acid and IBS.Results and conclusion. It has been established that combination therapy with these drugs for two weeks in 97 % of cases eliminates the clinical symptoms of the syndromes, improves the quality of life of patients, normalizes intestinal motility and myoelectric activity of the gastrointestinal tract.
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