感染 SARS-CoV-2 后多发性硬化症患者纤维蛋白/纤维蛋白原降解产物的特征

PhD Tetiana Halenova, T. Halenova, N. G. Raksha, T. B. Vovk, V. Karbovskyy, S. Sholomon, V. Melnyk, O. M. Savchuk
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摘要

背景。本研究旨在调查有和没有2019年冠状病毒病(COVID-19)病史的多发性硬化症(MS)患者血浆中纤维蛋白原及其降解产物的水平。材料和方法我们对 97 名多发性硬化症患者进行了检查。根据是否存在COVID-19,所有病例被分为两组。MS组包括56名既往未患COVID-19的患者。MS + COVID 组包括 41 例经实验室确诊患有 COVID-19 的患者。健康对照组包括 30 名健康志愿者。采用分光光度法测量纤维蛋白原、D-二聚体和可溶性纤维蛋白单体复合物(SFMC)的浓度。尺寸排阻色谱法用于分析 SFMC 分馏物的组成。结果。我们发现,与健康对照组相比,所有多发性硬化症患者血浆中纤维蛋白原、D-二聚体和 SFMC 的浓度均显著升高。两组多发性硬化症患者的 D-二聚体和 SFMCs 水平没有差异,而多发性硬化症 + COVID 患者的血浆纤维蛋白原浓度比多发性硬化症组明显升高。此外,与健康对照组相比,多发性硬化症的发生伴随着 SFMC 组成数量和质量的变化。我们的研究结果表明,多发性硬化症患者血浆中高分子量 SFMCs 的积累。结论。研究结果表明,多发性硬化症患者的止血特征发生了变化;然而,要确定特定止血因子(即纤维蛋白原、D-二聚体和 SFMCs)与多发性硬化症病理生理学之间的联系,还需要更多的研究。
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Characteristics of fibrin/fibrinogen degradation products in multiple sclerosis following SARS-CoV-2 infection
Background. The purpose of this study was to investigate plasma levels of fibrinogen and products of its degradation in patients with multiple sclerosis (MS) with and without a history of coronavirus disease 2019 (COVID-19). Materials and methods. We examined 97 patients with MS. Based on the presence of COVID-19, all cases were divided into two groups. MS group included 56 patients who did not suffer from COVID-19 previously. MS + COVID group consisted of 41 cases who had a laboratory-verified diagnosis of COVID-19. The group of healthy controls included 30 healthy volunteers. Spectrophotometric techniques were used to measure the concentrations of fibrinogen, D-dimer, and soluble fibrin monomer complexes (SFMCs). Size-exclusion chromatography was applied to analyze the composition of SFMC fractions. Results. We found that concentrations of fibrinogen, D-dimer, and SFMCs were remarkably increased in plasma of all MS patients compared with healthy controls. The levels of D-dimer, and SFMCs did not differ between two MS groups, while plasma fibrinogen concentration was significantly increased in MS + COVID patients compared to MS group. Moreover, the development of MS was accompanied by the changes in both quantity and quality of SFMC composition compared to that of healthy controls. Our results demonstrated accumulation of high-molecular-weight SFMCs in plasma of MS patients. Conclusions. The findings indicated that MS patients had changed hemostasis characteristics; however, more research is required to determine the connection between particular hemostatic factors, namely fibrinogen, D-dimer, and SFMCs, and the pathophysiology of MS.
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