Zheng Zhu, Bizhi Tu, Run Fang, Jun Tong, Yulong Liu, Rende Ning
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引用次数: 0
摘要
这些基因与免疫相关细胞浸润和炎症细胞因子水平有关。此外，我们还观察到 OA 不同群组中枢基因表达模式的异质性。值得注意的是，老年患者更容易出现疼痛相关炎性细胞因子水平升高和免疫细胞浸润。结论与 SMP 相关的枢纽基因有可能成为 OA 患者的诊断标志物。此外，SMP 的 4 个枢纽基因广泛参与了 OA 滑膜的免疫失调。在不同的 OA 患者人群中观察到了不同途径的激活。
Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Immune Dysregulation
genes showed associations with immune-related cell infiltration and levels of inflammatory cytokines. Furthermore, we observed heterogeneity in the expression patterns of hub genes across different clusters of OA. Notably, older patients displayed increased susceptibility to elevated levels of pain-related inflammatory cytokines and infiltration of immune cells. Conclusions: The SMP-related hub genes have the potential to serve as diagnostic markers for OA patients. Moreover, the 4 hub genes of SMP demonstrate wide participation in immune dysregulation in OA synovium. The activation of different pathways is observed among different populations of patients with OA.
期刊介绍：
ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications.
The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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