2-Iodoglycals 的交叉亲电偶联可高效获取 2-C-Glycals

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC Synlett Pub Date : 2024-05-06 DOI:10.1055/a-2320-6209

Shuai Chen, Yang Han, Anrong Chen, Feng Zhu

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引用次数: 0

摘要

通过镍催化的 2-碘甘油与（杂）芳基碘化物的交叉亲电偶联反应，开发出了一种合成 2-C 甘氨酸的通用策略。该方法成功的关键在于使用了缺电子的双吡啶配体。这种创新方法有助于高效构建 2-C 糖醛，从而拓宽了糖化学合成的范围。

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Cross-Electrophile Coupling of 2-Iodoglycals Enables Efficient Access to 2-C-Glycals

A general strategy was developed for synthesizing of 2-C-glycals through a nickel-catalyzed cross-electrophile coupling reaction of 2-iodoglycals with (hetero)aryl iodides. Key to the success of this methodology is the use of an electron-deficient bipyridyl ligand. This innovative approach facilitates the efficient construction of 2-C-glycals, thereby broadening the synthetic repertoire available for glycochemistry.

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.