植入自动植入式心律转复除颤器 (AICD) 作为心脏肉样瘤病相关性室性心动过速的二级预防措施

Fares Saliba, Jonathan Mina, Laurence Aoun, Georges Khattar, Elie Bou Sanayeh, Omar Mourad, Saif Abu Baker
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摘要

背景:心脏肉样瘤病可引起多种症状,包括气短、胸痛、水肿和致命性心律失常,如室性心动过速(VT)。由于症状可能是非特异性的,因此诊断心脏肉样瘤病可能具有挑战性。治疗方法包括使用皮质类固醇减轻炎症反应、使用免疫抑制剂防止进一步损害、使用药物控制症状、进行消融手术以及使用除颤器防止心脏骤停。病例:一位 60 岁的妇女患有影响多个器官的肉瘤病,包括心脏肉瘤病、射血分数降低的非缺血性心肌病和高血压,入院时出现心动过速、呼吸急促,最近刚启动了自动植入式心律转复除颤器(AICD)。三个月前,患者因晕厥发作入院,通过心脏磁共振成像(MRI)和正电子发射断层扫描(PET)确诊为心脏肉样瘤病,显示炎症活跃,并植入了 AICD。入院期间,患者室性心动过速发作,接受了胺碘酮和利多卡因治疗。患者接受了类固醇、沙库比特利/缬沙坦和甲氨蝶呤治疗。经过 48 小时的观察后,患者康复出院,未再发生其他事件。结论心脏肉样瘤病是一种罕见但严重的疾病,可导致室性心动过速等危及生命的心脏并发症。早期诊断和积极治疗对改善预后和预防心脏性猝死至关重要。植入 AICD 作为心脏肉样瘤病的二级预防措施可预防心脏骤停。
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Automatic implantable cardioverter defibrillator (AICD) implantation as secondary prevention of cardiac sarcoidosis-associated ventricular tachycardia
  Background: Cardiac sarcoidosis can cause a wide range of symptoms, including shortness of breath, chest pain, oedema, and fatal arrhythmias such as ventricular tachycardia (VT). Because the symptoms can be nonspecific, diagnosing cardiac sarcoidosis can be challenging. Treatment options may include corticosteroids to reduce inflammation, immunosuppressive drugs to prevent further damage, medications to control symptoms, ablation procedures, and defibrillators to prevent cardiac arrest. Case: A 60-year-old woman who has sarcoidosis affecting multiple organs including cardiac sarcoidosis, non-ischemic cardiomyopathy with reduced ejection fraction, and hypertension, was admitted with tachycardia, shortness of breath, and a recently fired automatic implantable cardioverter defibrillator (AICD). Three months prior, the patient was admitted for a syncopal episode and diagnosed with cardiac sarcoidosis through cardiac magnetic resonance imaging (MRI) and positron emission tomography (PET), which demonstrated active inflammation, and an AICD was implanted. During this admission, the patient had an episode of ventricular tachycardia and was treated with amiodarone and lidocaine. The patient received steroids, sacubitril/valsartan, and methotrexate. After 48 hours of observation, the patient was discharged without further events. Conclusion: Cardiac sarcoidosis is a rare but serious disease that can lead to life-threatening cardiac complications such as ventricular tachycardia. Early diagnosis and aggressive management are crucial for improving outcomes and preventing sudden cardiac death. AICD implantation as a secondary prevention in cardiac sarcoidosis might prevent cardiac arrest.
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