免疫性细胞死亡相关分子亚型的特征及其对前列腺癌的治疗意义

IF 2.9 4区 医学 Q1 Medicine Journal of biomedical nanotechnology Pub Date : 2024-05-01 DOI:10.1166/jbn.2024.3830
Jie Yang, Chao Wang, Chuan Zhou, Zijian Da, Fenghai Zhou
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引用次数: 0

摘要

本研究调查了前列腺腺癌(PRAD)中与免疫原性细胞死亡(ICD)相关的基因表达模式,探索了 ICD 激活诱导抗癌效应的潜力,并确定了 PRAD 的分子亚型。研究人员使用R软件分析了来自TCGA和GEO的数据集,以评估与ICD相关的基因表达变化。上调基因包括EIF2AK3、FOXP3、BAX、PDIA3、CALR和CASP8,下调基因包括IL1R、PIK3CA、IL17A等。Western 印迹证实了 EIF2AK3、FOXP3、BAX、PDIA3、CALR 和 CASP8 的上调。根据 33 个 ICD 相关基因对 497 个样本进行聚类,发现了三种分子亚型,它们具有不同的基因功能和不同的 PD-L1 表达水平。PRAD肿瘤微环境表现出大量静息树突状细胞和罕见的活化树突状细胞。这项研究表明,PRAD中表达了多种ICD相关基因,从而划分出三种分子亚型,可指导分子水平的精确治疗。此外,PRAD肿瘤微环境中静止树突状细胞的存在也暗示了基于ICD的疗法激活这些细胞以达到抗肿瘤效果的潜力。
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Characterization of Immunogenic Cell Death Related Molecular Subtypes and Its Therapeutic Implications for Prostate Adenocarcinoma
This study investigates immunogenic cell death (ICD)-related gene expression patterns in prostate adenocarcinoma (PRAD), explores the potential for ICD activation to induce anticancer effects, and identifies molecular subtypes in PRAD. Datasets from TCGA and GEO were analyzed using R software to assess ICD-related gene expression changes. Up-regulated genes included EIF2AK3, FOXP3, BAX, PDIA3, CALR, and CASP8, while down-regulated genes included IL1R, PIK3CA, IL17A, and others. Western blot confirmation supported the up-regulation of EIF2AK3, FOXP3, BAX, PDIA3, CALR, and CASP8. Clustering 497 samples based on 33 ICD-related genes revealed three molecular subtypes, with distinct gene functions and varying PD-L1 expression levels. The PRAD tumor microenvironment exhibited an abundance of resting dendritic cells and rare activated dendritic cells. This study suggests that diverse ICD-related genes are expressed in PRAD, leading to the classification of three molecular subtypes, which could guide precise molecular-level treatments. Additionally, the presence of resting dendritic cells in the PRAD tumor microenvironment hints at the potential for ICD-based therapies to activate these cells for anti-tumor effects.
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来源期刊
CiteScore
4.30
自引率
17.20%
发文量
145
审稿时长
2.3 months
期刊介绍: Information not localized
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