Evaluation of the Cyanoacrylate/Polymethylmethacrylate Complex as a Protectant to Prevent Skin Friction and Blisters

The skin is highly susceptible to friction during labor or outdoor activities, leading to blisters, bleeding, pain, and infection. In this paper, a butyl-cyanoacrylate/polymethylmethacrylate (504/PMMA) composite was developed as a protectant to prevent skin damage caused by external friction. The composite could rapidly solidify on the skin surface, forming a strong polymer film. Results from a rat model showed that the 504/PMMA composite effectively prevented skin damage and that increasing the proportion of PMMA improved its anti-friction performance. Moreover, the material is biocompatible. In this study, we offered new options for reducing skin friction and blisters, which have potential to practical applications.