细胞与其环境之间关系的改变是病理状态的基础

IF 1.5 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Critical Reviews in Eukaryotic Gene Expression Pub Date : 2024-05-01 DOI:10.1615/critreveukaryotgeneexpr.2024053711

Domenico RIBATTI

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引用次数: 0

摘要

病理状态可被视为不同组织和器官的细胞与周围微环境（主要是细胞外基质的不同成分）之间关系的改变。上皮-间质转化就是一个例子，说明上皮细胞之间关系的改变如何引起其表型特征的改变，并诱发其迁移和侵袭能力。

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The alteration of the relationship between cells and their context is the basis of a pathological condition

Pathological conditions can be considered as alterations in the relationships between the cells of different tissues and organs and the microenvironment that surrounds them, primarily the different constituents of the extracellular matrix. The epithelial-mesenchymal transition is an example of how alterations in the relationships between epithelial cells can induce an alteration of their phenotypic characteristics and induce their migratory and invasive capacity.

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来源期刊

Critical Reviews in Eukaryotic Gene Expression 生物-生物工程与应用微生物

CiteScore

2.70

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Critical ReviewsTM in Eukaryotic Gene Expression presents timely concepts and experimental approaches that are contributing to rapid advances in our mechanistic understanding of gene regulation, organization, and structure within the contexts of biological control and the diagnosis/treatment of disease. The journal provides in-depth critical reviews, on well-defined topics of immediate interest, written by recognized specialists in the field. Extensive literature citations provide a comprehensive information resource. Reviews are developed from an historical perspective and suggest directions that can be anticipated. Strengths as well as limitations of methodologies and experimental strategies are considered.