膀胱癌临床前模型:BBN 及其他

IF 12.1 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-05-20 DOI:10.1038/s41585-024-00885-9
David Matye, Juliann Leak, Benjamin L. Woolbright, John A. Taylor
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引用次数: 0

摘要

临床前建模是促进对癌症生物学和疗法开发的理解的重要组成部分。有几种模型可用于了解膀胱癌的病理生物学和评估治疗方法。N-丁基-N-(4-羟基丁基)-亚硝胺(BBN)诱导的膀胱癌是一种常用的模型,它再现了人类疾病的许多特征。特别是在小鼠中,BBN 是一种首选的实验室模型,因为它具有高度的可重复性、与人类病症高度的遗传保真度以及相对易用性。然而,该模型的一些重要方面在实验室研究中往往被忽视。此外,新模型的出现产生了多种方法来补充 BBN 的使用。毒物动力学、组织病理学、分子遗传学和性别在不同的可用模型中可能会有所不同,这些都是膀胱癌建模中需要考虑的重要因素。
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Preclinical models of bladder cancer: BBN and beyond

Preclinical modelling is a crucial component of advancing the understanding of cancer biology and therapeutic development. Several models exist for understanding the pathobiology of bladder cancer and evaluating therapeutics. N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)-induced bladder cancer is a commonly used model that recapitulates many of the features of human disease. Particularly in mice, BBN is a preferred laboratory model owing to a high level of reproducibility, high genetic fidelity to the human condition, and its relative ease of use. However, important aspects of the model are often overlooked in laboratory studies. Moreover, the advent of new models has yielded a variety of methodologies that complement the use of BBN. Toxicokinetics, histopathology, molecular genetics and sex can differ between available models and are important factors to consider in bladder cancer modelling.

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来源期刊
Nature Reviews Urology
Nature Reviews Urology 医学-泌尿学与肾脏学
CiteScore
12.50
自引率
2.60%
发文量
123
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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