年龄只是老年肾移植患者的一个数字

IF 5.3 2区 医学 Q1 IMMUNOLOGY Transplantation Pub Date : 2025-01-01 Epub Date: 2024-05-21 DOI:10.1097/TP.0000000000005073
Evelien E Quint, Robert A Pol, Dorry L Segev, Mara A McAdams-DeMarco
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引用次数: 0

摘要

全球人口平均年龄的上升导致老年肾移植(KT)患者的增加。这种人口结构的变化,再加上持续的器官短缺,要求我们对哪些老年人最适合接受肾移植有一个细致入微的了解。由于认识到老年人之间的异质性增加以及仅依赖于纪年年龄的局限性,有必要探索纪年年龄之外的其他衰老指标。在这篇综述中,我们讨论了老年人对接受 KT 和术后结果的影响。我们强调需要进行超越生理年龄的全面评估,并探讨了衰弱、肌肉疏松症和认知功能等替代性衰老指标,强调了它们在加强 KT 评估过程中的潜在作用。最重要的是,我们的目标是为正在进行的讨论做出贡献,为快速增长的老年人群提供优化的 KT 方法。
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Age Is Just a Number for Older Kidney Transplant Patients.

The rise in the mean age of the global population has led to an increase in older kidney transplant (KT) patients. This demographic shift, coupled with the ongoing organ shortage, requires a nuanced understanding of which older adults are most suitable for KT. Recognizing the increased heterogeneity among older adults and the limitations of solely relying on chronological age, there is a need to explore alternative aging metrics beyond chronological age. In this review, we discuss the impact of older age on access to KT and postoperative outcomes. Emphasizing the need for a comprehensive evaluation that extends beyond chronological age, we explore alternative aging metrics such as frailty, sarcopenia, and cognitive function, underscoring their potential role in enhancing the KT evaluation process. Most importantly, we aim to contribute to the ongoing discourse, fostering an optimized approach to KT for the rapidly growing population of older adults.

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来源期刊
Transplantation
Transplantation 医学-免疫学
CiteScore
8.50
自引率
11.30%
发文量
1906
审稿时长
1 months
期刊介绍: The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation. ​
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