组蛋白/DNA 修饰与 RNA N6-甲基腺苷修饰之间的相互影响

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-05-21 DOI:10.1016/j.gde.2024.102205
Yushuai Wang , Huilin Huang , Jianjun Chen , Hengyou Weng
{"title":"组蛋白/DNA 修饰与 RNA N6-甲基腺苷修饰之间的相互影响","authors":"Yushuai Wang ,&nbsp;Huilin Huang ,&nbsp;Jianjun Chen ,&nbsp;Hengyou Weng","doi":"10.1016/j.gde.2024.102205","DOIUrl":null,"url":null,"abstract":"<div><p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post-transcription levels. Complex interplay between m<sup>6</sup>A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m<sup>6</sup>A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m<sup>6</sup>A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m<sup>6</sup>A-based epigenetic network.</p></div>","PeriodicalId":50606,"journal":{"name":"Current Opinion in Genetics & Development","volume":"86 ","pages":"Article 102205"},"PeriodicalIF":3.7000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0959437X24000546/pdfft?md5=c27e26ed84d30b55cd9e4436f1274526&pid=1-s2.0-S0959437X24000546-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification\",\"authors\":\"Yushuai Wang ,&nbsp;Huilin Huang ,&nbsp;Jianjun Chen ,&nbsp;Hengyou Weng\",\"doi\":\"10.1016/j.gde.2024.102205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post-transcription levels. Complex interplay between m<sup>6</sup>A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m<sup>6</sup>A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m<sup>6</sup>A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m<sup>6</sup>A-based epigenetic network.</p></div>\",\"PeriodicalId\":50606,\"journal\":{\"name\":\"Current Opinion in Genetics & Development\",\"volume\":\"86 \",\"pages\":\"Article 102205\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0959437X24000546/pdfft?md5=c27e26ed84d30b55cd9e4436f1274526&pid=1-s2.0-S0959437X24000546-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Genetics & Development\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0959437X24000546\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Genetics & Development","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0959437X24000546","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

N6-甲基腺苷(m6A)是真核生物信使核糖核酸(mRNA)中最常见的内部核糖核酸修饰,在转录和转录后水平调节基因表达。近年来,m6A 与组蛋白修饰和 DNA 修饰等其他已被充分研究的表观遗传修饰之间复杂的相互作用已被广泛报道。RNA m6A修饰与组蛋白/DNA修饰之间的相互影响在建立染色质状态以精确、特异地微调基因表达方面起着至关重要的作用,无疑对生理和病理过程都有深远的影响。在这篇综述中,我们讨论了 RNA m6A 修饰与组蛋白/DNA 修饰之间的相互影响,强调了它们之间的复杂沟通及其内在机制,从而全面了解基于 m6A 的表观遗传网络的生物学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Crosstalk between histone/DNA modifications and RNA N6-methyladenosine modification

N6-methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotic messenger RNAs (mRNAs), regulating gene expression at the transcription and post-transcription levels. Complex interplay between m6A and other well-studied epigenetic modifications, including histone modifications and DNA modification, has been extensively reported in recent years. The crosstalk between RNA m6A modification and histone/DNA modifications plays a critical role in establishing the chromatin state for the precise and specific fine-tuning of gene expression and undoubtedly has profound impacts on both physiological and pathological processes. In this review, we discuss the crosstalk between RNA m6A modification and histone/DNA modifications, emphasizing their sophisticated communications and the mechanisms underlying to gain a comprehensive view of the biological relevance of m6A-based epigenetic network.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
期刊最新文献
In vitro dynamics of DNA loop extrusion by structural maintenance of chromosomes complexes Novelty versus innovation of gene regulatory elements in human evolution and disease Editorial Board Circuit integration by transplanted human neurons Control of cell fate upon transcription factor–driven cardiac reprogramming
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1