微生物群与结直肠癌--控制混杂因素挑战关联性

IF 45.9 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY Nature Reviews Gastroenterology &Hepatology Pub Date : 2024-05-21 DOI:10.1038/s41575-024-00947-8
Katrina Ray
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引用次数: 0

摘要

最近的一项研究发现,在定量微生物组数据中控制混杂因素对某些报道的肠道微生物群与结肠直肠癌(CRC)分期之间关系的稳健性提出了挑战。该研究分析了589名处于不同阶段的CRC患者的粪便微生物群,并与多达15项已发表的研究(共计4439名患者和对照组)进行了比较。定量微生物组分析与严格的混杂因素控制相结合,确定了转运时间、粪便钙粘蛋白水平(一种肠道炎症标志物)和体重指数是主要的微生物协变量,它们超过了 CRC 诊断组(健康、腺瘤和癌)所解释的方差。值得注意的是,在控制了这些协变量后,众所周知的 CRC 微生物组成员(如核酸镰刀菌)与 CRC 诊断组别无关。相反,一系列不同的微生物,如阴道厌氧球菌和Dialister pneumosintes等,在统计学上都有显著的相关性。这些发现强调了在关联研究中考虑混杂因素的重要性。
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Microbiota and colorectal cancer — controlling for confounders challenges associations
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来源期刊
CiteScore
52.30
自引率
0.60%
发文量
147
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Gastroenterology & Hepatology aims to serve as the leading resource for Reviews and commentaries within the scientific and medical communities it caters to. The journal strives to maintain authority, accessibility, and clarity in its published articles, which are complemented by easily understandable figures, tables, and other display items. Dedicated to providing exceptional service to authors, referees, and readers, the editorial team works diligently to maximize the usefulness and impact of each publication. The journal encompasses a wide range of content types, including Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements, all pertinent to gastroenterologists and hepatologists. With its broad scope, Nature Reviews Gastroenterology & Hepatology ensures that its articles reach a diverse audience, aiming for the widest possible dissemination of valuable information. Nature Reviews Gastroenterology & Hepatology is part of the Nature Reviews portfolio of journals.
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