Ying Liu , Jiaqi Huang , Zhudi Sun , Yupian Deng , Yuhao Qian , Qingchun Huang , Song Cao
{"title":"由 α-(三氟甲基)苯乙烯和邻苯二甲酰亚胺两步合成邻位三氟甲基伯胺。","authors":"Ying Liu , Jiaqi Huang , Zhudi Sun , Yupian Deng , Yuhao Qian , Qingchun Huang , Song Cao","doi":"10.1039/d4ob00567h","DOIUrl":null,"url":null,"abstract":"<div><p>A novel two-step synthesis of β-trifluoromethyl primary amines from readily available α-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves a hydroamination between α-(trifluoromethyl)styrenes and phthalimide (PhthNH) with the assistance of a base. Next, the hydrazinolysis of the resulting <em>N</em>-(β-trifluoromethyl-β-arylethyl)phthalimides with hydrazine hydrate affords the desired <em>N</em>-(β-trifluoromethyl-β-arylethyl)amines.</p></div>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":null,"pages":null},"PeriodicalIF":2.9000,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide†\",\"authors\":\"Ying Liu , Jiaqi Huang , Zhudi Sun , Yupian Deng , Yuhao Qian , Qingchun Huang , Song Cao\",\"doi\":\"10.1039/d4ob00567h\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>A novel two-step synthesis of β-trifluoromethyl primary amines from readily available α-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves a hydroamination between α-(trifluoromethyl)styrenes and phthalimide (PhthNH) with the assistance of a base. Next, the hydrazinolysis of the resulting <em>N</em>-(β-trifluoromethyl-β-arylethyl)phthalimides with hydrazine hydrate affords the desired <em>N</em>-(β-trifluoromethyl-β-arylethyl)amines.</p></div>\",\"PeriodicalId\":96,\"journal\":{\"name\":\"Organic & Biomolecular Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-06-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic & Biomolecular Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S1477052024004749\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S1477052024004749","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Two-step synthesis of vicinal trifluoromethyl primary amines from α-(trifluoromethyl)styrenes and phthalimide†
A novel two-step synthesis of β-trifluoromethyl primary amines from readily available α-(trifluoromethyl)styrenes and phthalimide is developed. The first step involves a hydroamination between α-(trifluoromethyl)styrenes and phthalimide (PhthNH) with the assistance of a base. Next, the hydrazinolysis of the resulting N-(β-trifluoromethyl-β-arylethyl)phthalimides with hydrazine hydrate affords the desired N-(β-trifluoromethyl-β-arylethyl)amines.