Francesco De Leonardis, Vittorio Greco Miani, Silvia Vallese, Sabina Barresi, Giuseppe Marulli, Chiara Novielli, Patrizia Dall'Igna, Michele Maruccia, Nicola Santoro
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A Novel NUTM1-NSMCE2 Fusion Gene in a Pediatric Chest NUT Carcinoma.
Nuclear protein of the testis carcinoma is an exceedingly rare and poorly differentiated carcinoma characterized by BDR4::NUTM1 gene translocation. Typically, the tumor affects young adults, and no standardized recommendations for therapeutic management have been available since 2022; the clinical course remains mostly dismal. We report the successful multimodal treatment of a 13-year-old boy affected by a primary chest NUT-carcinoma with a novel NUTM1 rearrangement that remains in complete continuous remission at 30 months from diagnosis.
期刊介绍：
Journal of Pediatric Hematology/Oncology (JPHO) reports on major advances in the diagnosis and treatment of cancer and blood diseases in children. The journal publishes original research, commentaries, historical insights, and clinical and laboratory observations.
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