评估用于预测社区成人新发糖尿病和心血管疾病的血糖指标。

IF 3 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2024-11-01 Epub Date: 2024-05-21 DOI:10.1007/s12020-024-03876-3
Jung-Hwan Kim, Yaeji Lee, Chung-Mo Nam, Yu-Jin Kwon, Ji-Won Lee
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引用次数: 0

摘要

目的:糖尿病(DM)是一个全球关注的健康问题,与包括心血管疾病(CVD)在内的各种并发症有关。然而,在韩国普通人群中使用不同的血糖评估方法对糖尿病和心血管疾病风险进行的长期跟踪研究尚属空白。本研究旨在评估空腹血浆葡萄糖(FPG)、2 小时口服葡萄糖耐量试验(OGTT)和糖化血红蛋白(HbA1c)对韩国中老年人群中新发 DM 和高 CVD 风险的预测能力:本研究使用的数据来自韩国基因组与流行病学研究(Korean Genome and Epidemiology Study),这是一项基于人群的前瞻性队列研究。对血糖指标(FPG、OGTT 和 HbA1c)进行了检测。主要终点是新发糖尿病的发病情况,并使用弗雷明汉风险评分评估心血管疾病风险。使用哈雷尔一致性指数和 95% 置信区间评估了基于血糖值的新发糖尿病的预测能力:在 10,030 名参与者中,分析了 6813 名基线时未患有糖尿病的参与者的数据。研究显示,在预测新发糖尿病方面,OGTT 的效果优于 FPG 和 HbA1c。与单独进行OGTT相比,结合使用FPG和HbA1c并不能显著提高对DM的预测。在预测心血管疾病高风险方面,OGTT也优于FPG和HbA1c,即使在调整了其他混杂因素后,这一差异仍然显著:结论:在韩国人群中,OGTT 在识别新发糖尿病和心血管疾病高风险方面具有更强的预测能力。结论:在韩国人群中,OGTT 在识别新发糖尿病和心血管疾病高风险方面具有更强的预测能力,这表明仅依靠单个血糖指标可能不足以评估糖尿病和心血管疾病风险。
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Assessing blood sugar measures for predicting new-onset diabetes and cardiovascular disease in community-dwelling adults.

Purpose: Diabetes mellitus (DM) is a global health concern linked to various complications, including cardiovascular disease (CVD). However, long-term follow-up studies on the risk of DM and CVD using different blood glucose assessment methods in the general Korean population are lacking. This study aimed to assess the predictive abilities of fasting plasma glucose (FPG), 2-h oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) for new-onset DM and high CVD risk in a middle-aged and older Korean population.

Methods: This study used data from the Korean Genome and Epidemiology Study, a population-based prospective cohort. Blood sugar measures (FPG, OGTT, and HbA1c) were examined. The primary endpoint was the development of new-onset DM, and CVD risk was evaluated using the Framingham risk score. The predictive abilities for new-onset DM based on glycemic values were evaluated using Harrell's Concordance index and 95% confidence intervals.

Results: Among the 10,030 participants, data of 6813 participants without DM at baseline were analyzed. The study revealed that OGTT outperformed FPG and HbA1c in predicting new-onset DM. The combination of FPG and HbA1c did not significantly enhance predictions for DM compared with OGTT alone. OGTT also outperformed FPG and HbA1c in predicting high CVD risk, and this difference remained significant even after adjusting for additional confounders.

Conclusion: OGTT has superior predictive capabilities in identifying new-onset DM and high CVD risk in the Korean population. This suggests that relying solely on individual blood sugar measures may be insufficient for assessing DM and CVD risks.

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来源期刊
Endocrine
Endocrine ENDOCRINOLOGY & METABOLISM-
CiteScore
6.50
自引率
5.40%
发文量
295
审稿时长
1.5 months
期刊介绍: Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
期刊最新文献
Correction to: Therapeutic patient education and treatment intensification of diabetes and hypertension in subjects with newly diagnosed type 2 diabetes mellitus: a longitudinal study. Correction: Timing of the repeat thyroid fine-needle aspiration biopsy: does early repeat biopsy change the rate of nondiagnostic or atypia of undetermined significance cytology result? Hematological toxicities with Lutathera® for neuroendocrine neoplasms: post-marketing surveillance data from the US-FDA. SGLT2 inhibitors may reduce non-small cell lung cancer and not increase various neoplasms including several skin cancers. Clarification on the role of thyroid scintigraphy in the era of TIRADS: a response to Trimboli et al. (2024).
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