大隐静脉移植物外部支架可减少术后早期移植物失败。

0 CARDIAC & CARDIOVASCULAR SYSTEMS Interdisciplinary cardiovascular and thoracic surgery Pub Date : 2024-06-05 DOI:10.1093/icvts/ivae099
Stak Dushaj, Achim Häussler, Laura Rings, Vasileios Ntinopoulos, Nestoras Papadopoulos, Dragan Odavic, Hector Rodriguez Cetina Biefer, Omer Dzemali
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摘要

目的:多项研究表明,外支架置入术可减轻 CABG 术后数年静脉移植物疾病的进展。我们使用计算机断层扫描来评估外部支架对围手术期静脉移植物通畅性的影响:本研究评估了 2018 年至 2021 年连续隔离冠状动脉旁路移植术(CABG)患者的大隐静脉移植物(SVG)通畅率。以年龄、EurSCORE II、性别、糖尿病和动脉移植物作为协变量,进行了逻辑回归分析,以比较支持组和非支持组在患者和移植物层面的结果。根据不同的协变量进行了分组分析。该研究旨在为CABG患者SVG移植物的临床结果提供有价值的见解:研究共检查了 357 名符合纳入标准的患者,评估了 572 例静脉移植物。研究结果表明,支架植入组与未植入组相比,出院时 SVG 总体通畅的可能性更高,无论是在移植物层面(93.8% vs 87.8%,几率比 [OR] 2.1;95% 置信区间 [CI] 1.0-4.5;P = 0.05)和患者水平(90.1% vs 83.5%,OR 1.8;95% CI,0.9-3.6;P = 0.1)。值得注意的是,支架植入组和非支架植入组之间的差异在接受两次动脉移植的亚组(96.5% vs 89.6%,OR 3.2;95% CI,1.2-8.4;P = 0.02)和EuroSCORE II较高(中位数>1.1)的亚组(98.6% vs 88.6%,OR 8.8;95% CI,1.1-72.7;P = 0.04)中最为显著:ExSt与移植物和患者围手术期SVG通畅率的改善有关。此外,右侧区域的 SVG 和高危患者使用 ExSt 似乎更有优势。
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External stenting for saphenous vein grafts reduces early postoperative graft failure.

Objectives: Multiple studies have shown that external stenting (ExSt) mitigates the progression of vein graft disease years after coronary artery bypass grafting (CABG). We used computed tomography to evaluate the effect of ExSt on perioperative vein graft patency.

Methods: This study assessed graft patency rates of saphenous vein grafts (SVG) in consecutive patients with isolated coronary artery bypass grafting (CABG) between 2018 and 2021. Logistic regression analyses were conducted to compare the outcomes of supported and non-supported groups at both patient and graft levels, with age, EuroSCORE II, gender, diabetes and arterial grafts as covariates. Subgroup analyses were performed based on different covariates. The goal of the study was to provide valuable insights into the clinical outcomes of SVG in patients having CABG.

Results: The study examined a total of 357 patients who met the inclusion criteria and evaluated 572 vein grafts. Of these, 150 patients (205 SVGs) received ExSt, whereas 207 patients (337 SVGs) did not receive ExSt. The study results indicated that the likelihood of overall SVG patency at discharge was higher in the stented group than in the non-stented group, both at the level of the grafts [93.8% vs 87.8%, odds ratio (OR) 2.1; 95% confidence interval (CI) 1.0-4.5; P = 0.05] and at the patient level (90.1% vs 83.5%, OR 1.8; 95% CI 0.9-3.6; P = 0.1). It is worth noting that the difference between the stented and non-stented groups was most significant in the subgroup that received 2 arterial grafts (96.5% vs 89.6%, OR 3.2; 95% CI 1.2-8.4; P = 0.02) and in the subgroup with a higher EuroSCORE II (median >1.1) (98.6% vs 88.6%, OR 8.8; 95% CI 1.1-72.7; P = 0.04).

Conclusions: The ExSt is associated with improved perioperative SVG patency at both the graft and the patient levels. Moreover, SVGs to the right territory and high-risk patients appear to have an advantage using ExSt.

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