尼古丁会导致主动脉壁血管狭窄。

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Biotechnic & Histochemistry Pub Date : 2024-05-23 DOI:10.1080/10520295.2024.2352724
Hirona Kugo, Tatsuya Moriyama, Nobuhiro Zaima
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引用次数: 0

摘要

腹主动脉瘤(AAA)是一种涉及主动脉壁扩张的血管疾病。吸烟是导致主动脉瘤破裂的既定风险因素,尼古丁可能是导致主动脉瘤发病的主要因素。在人体中,这种疾病与血管狭窄有关,而血管狭窄可能是由尼古丁引起的。在这项研究中,我们评估了尼古丁对血管病理学的影响。使用渗透泵给大鼠注射尼古丁 4 周后,尼古丁注射组的血管通畅率明显低于对照组。尼古丁组大鼠VV区域的细胞增殖标记物Ki-67水平明显升高,缺氧诱导因子-α水平也明显升高。尼古丁组 VV 周围的胶原蛋白水平明显低于对照组。我们的数据表明,尼古丁可通过诱导VV平滑肌细胞异常增殖而导致VV狭窄。尼古丁诱导的 VV 变性和胶原纤维降解可能部分解释了吸烟导致 AAA 发生风险增加的原因。
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Nicotine induces vasa vasorum stenosis in the aortic wall.

Abdominal aortic aneurysm (AAA) is a vascular disease that involves aortic wall dilation. Cigarette smoking is an established risk factor and rupture, and nicotine may be a major contributor to the onset of AAA. In humans the condition is associated with stenosis of the vasa vasorum (VV), which may be caused by nicotine. In this study, we evaluated the effects of nicotine on VV pathology. After 4 weeks of nicotine administration to rats using an osmotic pump, the VV patency rate in the nicotine administration group was significantly lower than that in the control group. The levels of Ki-67, a cell proliferation marker, were significantly increased in the regions containing VV in the nicotine group, as were hypoxia inducible factor-α levels. Collagen levels around VV were significantly lower in the nicotine group than in the controls. Our data suggest that nicotine can cause VV stenosis by inducing abnormal proliferation of smooth muscle cells in the VV. The increased risk of AAA development due to cigarette smoking may be partially explained by nicotine-induced VV denaturation and collagen fiber degradation.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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