儿童和青少年患者中的黑色素瘤。

IF 4.7 2区 医学 Q1 ONCOLOGY Current Oncology Reports Pub Date : 2024-07-01 Epub Date: 2024-05-23 DOI:10.1007/s11912-024-01542-5
Vernon K Sondak, Jane L Messina
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引用次数: 0

摘要

综述的目的:年轻患者黑色素瘤的临床表现、组织学特征和预后与年长患者不同。这篇综述总结了儿童和年轻成人黑色素瘤的主要区别和重要的新见解,以及治疗方面的最新进展:最新发现:分子技术改进了黑色素细胞肿瘤的分类,尤其适用于这一年龄组经常出现的具有诊断难度的病变。分子评估强调了黑色素瘤与具有斯皮茨样形态的非典型病变之间的差异,应常规用于斯皮茨样黑色素细胞的诊断和分类,以指导预后和治疗。一旦确诊,儿童和青少年真正黑色素瘤的治疗方法与老年患者基本相似,而非典型 Spitz 肿瘤等病变的最佳治疗方法仍不确定。提高对青少年黑色素瘤的表现和诊断特点的认识将有助于更早地发现黑色素瘤,而诊断技术的改进将有助于在不过度治疗或治疗不足的情况下进行最佳治疗。
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Melanoma in Pediatric and Young Adult Patients.

Purpose of review: Melanoma in younger individuals has different clinical presentations, histologic characteristics and prognosis from older patients. This review summarizes key differences and important new insights into pediatric and young adult melanoma, as well as recent evolutions in treatment.

Recent findings: Molecular techniques have improved the classification of melanocytic neoplasms, and are especially useful in the workup of the diagnostically challenging lesions frequent in this age group. Molecular evaluation highlights differences between melanoma and atypical lesions with Spitz-like morphology, and should routinely be incorporated for diagnosing and classifying Spitzoid melanocytic to guide prognostication and treatment. Once diagnosed, the management of bona fide melanoma in children and young adults is largely similar to older patients, while the optimal management of lesions such as atypical Spitz tumors remains uncertain. Increased awareness of the presentation and diagnostic characteristics of melanoma in young individuals will allow earlier detection, and improved diagnostic techniques will allow optimum management without over- or under-treatment.

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来源期刊
CiteScore
8.50
自引率
0.00%
发文量
187
审稿时长
6-12 weeks
期刊介绍: This journal aims to review the most important, recently published clinical findings in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care of those affected by cancer. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as cancer prevention, leukemia, melanoma, neuro-oncology, and palliative medicine. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.
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