用磁共振弹性成像技术定量测量与衰老相关的心肌僵化的性别差异

IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiology. Cardiothoracic imaging Pub Date : 2024-06-01 DOI:10.1148/ryct.230140
Arvin Arani, Matthew C Murphy, Huzefa Bhopalwala, Shivaram P Arunachalam, Phillip J Rossman, Joshua D Trzasko, Kevin Glaser, Yi Sui, Tina Gunderson, Adelaide M Arruda-Olson, Armando Manduca, Kejal Kantarci, Richard L Ehman, Philip A Araoz
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Linear regression models were used to estimate the association of cardiac MRI and MRE characteristics with age and sex; models were also fit to assess potential age-sex interaction. Results Myocardial shear stiffness significantly increased with age in female (age slope = 0.03 kPa/year ± 0.01, <i>P</i> = .009) but not male (age slope = 0.008 kPa/year ± 0.009, <i>P</i> = .38) volunteers. LV ejection fraction (LVEF) increased significantly with age in female volunteers (0.23% ± 0.08 per year, <i>P</i> = .005). LV end-systolic volume (LVESV) decreased with age in female volunteers (-0.20 mL/m<sup>2</sup> ± 0.07, <i>P</i> = .003). MRI parameters, including T1, strain, and LV mass, did not demonstrate this interaction (<i>P</i> > .05). 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引用次数: 0

摘要

目的 探讨使用定量磁共振弹性成像(MRE)来描述年龄和性别对左心室剪切硬度影响的可行性。材料和方法 在这项前瞻性研究中,对2018年11月至2019年9月期间入组的109名健康志愿者(年龄范围:18-84岁;平均年龄为40岁±18[SD];57名女性,52名男性)进行了左心室心肌剪切刚度测量,在临床MRI方案中增加了5分钟的MRE采集。线性回归模型用于估算心脏 MRI 和 MRE 特征与年龄和性别的关系;模型还用于评估潜在的年龄-性别交互作用。结果 女性(年龄斜率 = 0.03 kPa/year ± 0.01,P = .009)而非男性(年龄斜率 = 0.008 kPa/year ± 0.009,P = .38)志愿者的心肌剪切硬度随着年龄的增长而显著增加。女性志愿者的左心室射血分数(LVEF)随着年龄的增长而显著增加(每年 0.23% ± 0.08,P = .005)。女性志愿者的左心室收缩末期容积(LVESV)随着年龄的增长而下降(-0.20 mL/m2 ± 0.07,P = .003)。磁共振成像参数,包括 T1、应变和左心室质量,并未显示出这种相互作用(P > .05)。心肌剪切僵硬度与 LVEF、LV 搏出量、体重指数或任何 MRI 应变指标无明显相关性(P > .05),但与 LV 舒张末期容积/体表面积 (BSA) (斜率 = -3 kPa/mL/m2±1,P = .004,r2 = 0.08)和 LVESV/BSA (-1.6 kPa/mL/m2±0.5,P = .003,r2 = 0.08)有明显相关性。结论 该研究表明,女性(而非男性)会随着自然衰老而经历不成比例的左心室僵化,而这些变化可通过 MRE 进行无创测量。关键词心脏 弹性成像 生物效应 实验研究 性二态性 磁共振弹性成像 心肌剪切僵硬度 定量僵硬度成像 衰老的心脏 心肌生物力学 心脏MRE 本文有补充材料。以 CC BY 4.0 许可发布。
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Sex Differences in Aging-related Myocardial Stiffening Quantitatively Measured with MR Elastography.

Purpose To investigate the feasibility of using quantitative MR elastography (MRE) to characterize the influence of aging and sex on left ventricular (LV) shear stiffness. Materials and Methods In this prospective study, LV myocardial shear stiffness was measured in 109 healthy volunteers (age range: 18-84 years; mean age, 40 years ± 18 [SD]; 57 women, 52 men) enrolled between November 2018 and September 2019, using a 5-minute MRE acquisition added to a clinical MRI protocol. Linear regression models were used to estimate the association of cardiac MRI and MRE characteristics with age and sex; models were also fit to assess potential age-sex interaction. Results Myocardial shear stiffness significantly increased with age in female (age slope = 0.03 kPa/year ± 0.01, P = .009) but not male (age slope = 0.008 kPa/year ± 0.009, P = .38) volunteers. LV ejection fraction (LVEF) increased significantly with age in female volunteers (0.23% ± 0.08 per year, P = .005). LV end-systolic volume (LVESV) decreased with age in female volunteers (-0.20 mL/m2 ± 0.07, P = .003). MRI parameters, including T1, strain, and LV mass, did not demonstrate this interaction (P > .05). Myocardial shear stiffness was not significantly correlated with LVEF, LV stroke volume, body mass index, or any MRI strain metrics (P > .05) but showed significant correlations with LV end-diastolic volume/body surface area (BSA) (slope = -3 kPa/mL/m2 ± 1, P = .004, r2 = 0.08) and LVESV/BSA (-1.6 kPa/mL/m2 ± 0.5, P = .003, r2 = 0.08). Conclusion This study demonstrates that female, but not male, individuals experience disproportionate LV stiffening with natural aging, and these changes can be noninvasively measured with MRE. Keywords: Cardiac, Elastography, Biological Effects, Experimental Investigations, Sexual Dimorphisms, MR Elastography, Myocardial Shear Stiffness, Quantitative Stiffness Imaging, Aging Heart, Myocardial Biomechanics, Cardiac MRE Supplemental material is available for this article. Published under a CC BY 4.0 license.

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