冠心病急性心肌梗死和稳定型心绞痛阶段细胞因子表达的比较。

IF 0.2 Q4 MEDICINE, RESEARCH & EXPERIMENTAL International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01
Wenwen Yan, Siwan Wen, Lemin Wang, Qianglin Duan, Lin Ding
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引用次数: 0

摘要

目的研究急性心肌梗死(AMI)患者、稳定性心绞痛(SA)患者和对照组细胞因子基因表达的差异,并比较其对免疫功能的影响。采用全基因组芯片分析法检测三组患者外周血单核细胞(PBMCs)中干扰素、白细胞介素、趋化因子、肿瘤坏死因子及相关受体的基因表达差异:结果:与 SA 患者和对照组相比,AMI 患者的 IFNα2、IFNαR1、IFNαR2、IFNγR1、IFNγR2、L1β、IL16、IL18、Cxcl1、Cxcl2、Cxcl6、CxcR2、CxcR4、LIGHT、TNFR1、LT-βR、CD137、TRAILR 和 TWEAKR mRNA 表达明显上调(PConclusion:在 AMI 患者中,细胞因子 mRNA 表达水平失衡,表明免疫系统功能紊乱。此外,在 SA 和对照组之间未观察到细胞因子的明显变化,这表明 AMI 和 SA 患者与细胞因子相关的免疫活性不同。
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Comparison of cytokine expressions in acute myocardial infarction and stable angina stages of coronary artery disease.

Objective: To investigate the differential gene expression of cytokines and compare their impacts on the immune functions among the acute myocardial infarction patients (AMI), the stable angina patients (SA) and the controls.

Methods: 20 patients with AMI, 20 patients with SA and 20 healthy volunteers were recruited into the study. Whole human genome microarray analysis was used to detect the gene expression differences in interferons, interleukins, chemokines, tumor necrosis factors and associated receptors in peripheral blood mononuclear cells (PBMCs) among three groups.

Results: Compared with SA patients and the controls respectively, in AMI patients, IFNα2, IFNαR1, IFNαR2, IFNγR1, IFNγR2, L1β, IL16, IL18, Cxcl1, Cxcl2, Cxcl6, CxcR2, CxcR4, LIGHT, TNFR1, LT-βR, CD137, TRAILR, and TWEAKR mRNA expressions were significantly up-regulated (P<0.05), while Ccl5, Ccl24, Ccl28, CcR5, TWEAK, CD40, CD27, and BAFFR mRNA expressions were significantly down-regulated (P<0.05). But, there was no significant difference in cytokine expression between the SA patients and the controls.

Conclusion: In AMI patients, mRNA expression levels of cytokines were imbalanced, indicating the dysfunction of the immune system. Together with no significant change of cytokines was observed between the SA and controls, showing the different cytokine related immune activity in the AMI and SA patients.

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