残余肾功能：一把双刃剑。

IF 2.3 4区医学 Q2 PERIPHERAL VASCULAR DISEASE Kidney & blood pressure research Pub Date : 2024-01-01 Epub Date: 2024-05-22 DOI:10.1159/000539108

Sandra Karanović Štambuk, Margareta Fištrek-Prlić, Bojan Jelaković

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引用次数: 0

摘要

导言：肾病综合征在肾病晚期仍可能持续存在，并导致血脂异常、血栓形成和心血管风险显著增加。难治性肾病综合征的治疗包括外科双侧肾切除术、肾动脉栓塞术和药物肾切除术：我们介绍了一例接受药物性肾切除术的难治性肾病综合征血液透析患者。该手术降低了患者的心血管风险，并使患者成为肾移植的候选者：结论：在某些情况下，残余肾功能可能是有害的。结论：在某些情况下，残余肾功能可能是有害的，在这种情况下，应考虑肾切除术。使用肾毒性药物进行药理肾切除术是一种非侵入性方法，潜在并发症最少。

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Residual Renal Function: A Double-Edged Sword.

Introduction: Nephrotic syndrome may persist despite end-stage kidney disease and result in dyslipidaemia, thrombosis and a significantly increased cardiovascular risk. Treatment of refractory nephrotic syndrome includes surgical bilateral nephrectomy, renal artery embolization and pharmacologic nephrectomy.

Case presentation: We present a case of a haemodialysis patient with refractory nephrotic syndrome who underwent pharmacologic nephrectomy. The procedure decreased the patient's cardiovascular risk and enabled the patient to become a candidate for kidney transplantation.

Conclusion: In certain situations residual renal function may be harmful. In such instances, nephrectomy should be considered. Pharmacologic nephrectomy using nephrotoxic drugs is a non-invasive approach with least potential complications.

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.