白细胞介素-1 通过 P50/P52 信号通路增加人 Granulosa-Lutein 细胞中 SERPINE1 的表达。

IF 3.8 3区 医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-05-20 DOI:10.1016/j.mce.2024.112274
Yu Xiang , Shuangying Liu , Shan Wan , Qingqing Chen , Yang Song , Guofang Feng , Xinyue Zhang , Long Bai , Yimin Zhu
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引用次数: 0

摘要

据报道,免疫因素与多囊卵巢综合征(PCOS)的发生有关。白细胞介素-1(IL-1)是白细胞介素家族的一员,广泛参与调节免疫系统的炎症反应。此外,据报道,血清中 IL-1 的异常积累与多囊卵巢综合症的发生有关。然而,人们对 IL-1 如何参与 PCOS 的发病机制知之甚少。本研究表明,PCOS 患者卵泡液中的免疫微环境发生了改变,两种 IL-1 细胞因子(IL-1α 和 IL-1β)的表达水平升高。转录组分析表明,IL-1α和IL-1β可诱导原代人颗粒-黄体(hGL)细胞炎症反应,并增加丝氨酸蛋白家族E成员1(SERPINE1)的表达。从机理上讲,我们证明了IL-1α和IL-1β通过IL-1R1介导的下游P50和P52信号通路激活人颗粒细胞中SERPINE1的表达。我们的研究强调了免疫状态变化在多囊卵巢综合征发生中的作用,并为治疗IL-1诱导的卵巢功能紊乱患者提供了新的见解。
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Interleukin-1 increases SERPINE1 expression in human granulosa-lutein cell via P50/P52 signaling pathways

It has been reported that immune factors are associated with the occurrence of polycystic ovary syndrome (PCOS). Interleukin-1 (IL-1) is a member of the interleukin family that widely participates in the regulation of the inflammatory response in the immune system. In addition, it has been reported that aberrant IL-1 accumulation in serum is associated with the occurrence of PCOS. However, little is known about how IL-1 participates in the pathogenesis of PCOS. In the present study, we demonstrated that the immune microenvironment was altered in follicular fluid from PCOS patients and that the expression levels of two IL-1 cytokines, IL-1α and IL-1β were increased. Transcriptome analysis revealed that IL-1α and IL-1β treatment induced primary human granulosa-lutein (hGL) cell inflammatory response and increased the expression of serpin family E member 1 (SERPINE1). Mechanistically, we demonstrated that IL-1α and IL-1β upregulated SERPINE1 expression through IL-1R1-mediated activation of downstream P50 and P52 signaling pathways in human granulosa cells. Our study highlighted the role of immune state changes in the occurrence of PCOS and provided new insight into the treatment of patients with IL-1-induced ovarian function disorders.

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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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