不同严重程度的 COVID-19 患者血清中的细胞因子和趋化因子概况

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-05-22 DOI:10.1016/j.cyto.2024.156653

Maryam Bourhis , Abderrazak Idir , Safa Machraoui , Abdelhamid Hachimi , Youssef Elouardi , Oumayma Jamil , Mohammed Khallouki , Kawtar Zahlane , Morad Guennouni , Raja Hazime , Lamiaa Essaadouni , Bouchra Lourhlam , Moulay Mustapha Ennaji , Hassan Ait Mouse , Brahim Admou , Abdelmajid Zyad

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引用次数: 0

摘要

导言：COVID-19 是一种病毒感染，会扰乱宿主的免疫系统，导致细胞因子过度分泌，引发细胞因子风暴。本研究旨在评估 27 种蛋白质生物标志物的血清水平，以确定它们与 COVID-19 疾病严重程度的关系。方法使用 Luminex 检测法（27 Bio-Plex Pro Human Cytokine，Bio-rad™）对 89 名 COVID-19 疾病严重程度不同的患者[无症状（14 人）、中度（14 人）、重度（30 人）和危重（31 人）]和 14 名健康人的血清水平进行 27 种细胞因子和趋化因子的检测。与其他组别相比，无症状患者的 IL-8 水平较高。IL-6、IL-10 和趋化因子 MIP-1α、MCP-1 和 IP10 的水平非常高，与疾病的进展有关，而 IL-4 则随着疾病的严重程度呈下降趋势。

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Cytokine and chemokine profiles in the sera of COVID-19 patients with different stage of severity

Introduction

COVID-19 is a viral infection that disturbs the host's immune system and causes an overproduction of cytokines leading to a cytokine storm. The present study aimed to evaluate the serum levels of 27 protein biomarkers to determine their association with COVID-19 disease severity.

Methods

The serum levels of 89 patients with different degrees of COVID-19 disease severity [asymptomatic (n = 14), moderate (n = 14), severe (n = 30), and critical (n = 31)] and 14 healthy individuals were tested for a panel of 27 cytokines and chemokines using Luminex assay (27 Bio‑Plex Pro Human Cytokine, Bio-rad™).

Results

IL-12, IL-2 and IL-13, as well as IL-17 and GM-CSF were clearly undetectable in asymptomatic patients. IL-8 levels were higher in asymptomatic compared with other groups. Very high levels of IL-6, IL-10 and the chemokines MIP-1α, MCP-1 and IP10 were associated with disease progression, while IL-4 tends to decrease with disease severity.

Conclusion

Our study provides more evidence that excessive cytokine synthesis is linked to the disease progression.

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.