GLP-1 信号对胰岛β细胞和胰腺外组织能量代谢的影响

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-05-22 DOI:10.1016/j.peptides.2024.171243
Leah A. Peart, Matthew Draper, Andrei I. Tarasov
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引用次数: 0

摘要

胰高血糖素样肽-1 信号影响葡萄糖稳态和食欲,从而间接影响全身的底物供应。增量素会产生促胰岛素效应,从而通过促进外周组织摄取和抑制糖的产生来降低血糖水平。同样,GLP-1 在中枢神经系统内的信号传导可降低食欲和食物摄入量,而其胃作用可延缓营养物质的吸收,从而改善血糖控制并降低餐后高血糖的风险。我们回顾了 GLP-1 信号的分子方面,重点是其对细胞内能量代谢的影响。增量蛋白主要通过 Gs 受体发挥其作用,Gs 受体将增量蛋白信号解码为细胞内 cAMP 水平的升高,细胞内的下游信号级联以快和慢的时间尺度发挥作用,分别导致葡萄糖分解代谢的增强或减弱。
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The impact of GLP-1 signalling on the energy metabolism of pancreatic islet β-cells and extrapancreatic tissues

Glucagon-like peptide-1 signalling impacts glucose homeostasis and appetite thereby indirectly affecting substrate availability at the whole-body level. The incretin canonically produces an insulinotropic effect, thereby lowering blood glucose levels by promoting the uptake and inhibiting the production of the sugar by peripheral tissues. Likewise, GLP-1 signalling within the central nervous system reduces the appetite and food intake, whereas its gastric effect delays the absorption of nutrients, thus improving glycaemic control and reducing the risk of postprandial hyperglycaemia. We review the molecular aspects of the GLP-1 signalling, focusing on its impact on intracellular energy metabolism. Whilst the incretin exerts its effects predominantly via a Gs receptor, which decodes the incretin signal into the elevation of intracellular cAMP levels, the downstream signalling cascades within the cell, acting on fast and slow timescales, resulting in an enhancement or an attenuation of glucose catabolism, respectively.

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来源期刊
Peptides
Peptides 医学-生化与分子生物学
CiteScore
6.40
自引率
6.70%
发文量
130
审稿时长
28 days
期刊介绍: Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.
期刊最新文献
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