瞄准和操纵蛋白质上的色氨酸相互作用。

IF 3.5 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY ACS Chemical Biology Pub Date : 2024-05-24 DOI:10.1021/acschembio.4c00267

Xiao Xie*, and , Shixian Lin*,

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引用次数: 0

摘要

色氨酸通常被认为埋藏在蛋白质的内核中以维持二级结构，但现在人们认识到它对蛋白质功能的重要贡献。然而，研究整个蛋白质组中色氨酸参与的功能性相互作用以及在活细胞中操纵这些相互作用是一项相当大的挑战。在这篇 "聚焦 "文章中，我们总结了该领域的新进展，介绍了利用吲哚分子独特的生化特性来靶向和功能性操纵色氨酸相互作用的创新化学方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Targeting and Manipulating Tryptophan Interactions on Proteins

Tryptophan, commonly regarded as buried within the interior cores of proteins to maintain secondary structures, is now being recognized for its significant contributions to protein functionality. However, investigating functional tryptophan-involved interactions across the proteome and manipulating these interactions in live cells are considerable challenges. In this In Focus article, we summarize emerging advances in the field, describing innovative chemistries that leverage distinctive biochemical properties of the indole moiety for targeting and functionally manipulating tryptophan interactions.

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来源期刊

ACS Chemical Biology 生物-生化与分子生物学

CiteScore

7.50

自引率

5.00%

发文量

353

审稿时长

3.3 months

期刊介绍： ACS Chemical Biology provides an international forum for the rapid communication of research that broadly embraces the interface between chemistry and biology. The journal also serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies. We welcome mechanistic studies on proteins, nucleic acids, sugars, lipids, and nonbiological polymers. The journal serves a large scientific community, exploring cellular function from both chemical and biological perspectives. It is understood that submitted work is based upon original results and has not been published previously.