树突状细胞与母体耐受性的建立有助于人类成功妊娠

IF 2.9 4区 医学 Q3 IMMUNOLOGY Archivum Immunologiae et Therapiae Experimentalis Pub Date : 2024-05-23 eCollection Date: 2024-01-01 DOI:10.2478/aite-2024-0010
Deviyani Mahajan, Tarun Kumar, Prasana Kumar Rath, Anjan Kumar Sahoo, Bidyut Prava Mishra, Sudarshan Kumar, Nihar Ranjan Nayak, Manoj Kumar Jena
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引用次数: 0

摘要

妊娠是一个非凡的事件,尽管存在遗传和免疫学差异,半同种异体胎儿仍在母亲的子宫中发育。孕期母胎界面的抗原处理和加工似乎对母体免疫系统的适应以及对发育中胎儿和胎盘的耐受性至关重要。母体抗原递呈细胞(APCs),如巨噬细胞(Mφs)和树突状细胞(DCs),在整个孕期都存在于母胎界面,并被认为在这一过程中发挥着关键作用。尽管有大量研究关注 Mφs 的重要性,但对 DC 在妊娠期间对胎儿-母体耐受性的贡献了解有限,这使其成为一个相对较新且不断发展的研究领域。本综述重点探讨了母胎界面上的 DCs 行为如何适应妊娠的独特需求。此外,它还讨论了 DC 如何与蜕膜白细胞网络中的其他细胞相互作用,以调节子宫和胎盘的稳态以及母体对胎儿的局部免疫反应。这篇综述特别研究了具有特定表面标志物的 DCs 不同细胞系,而以前的出版物尚未对这些细胞系进行严格审查。此外,它还强调了即使是微小的直流电功能紊乱也会对妊娠相关并发症产生影响,并建议进一步研究针对直流电的潜在治疗效果,以控制这些并发症。
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Dendritic Cells and the Establishment of Fetomaternal Tolerance for Successful Human Pregnancy.

Pregnancy is a remarkable event where the semi-allogeneic fetus develops in the mother's uterus, despite genetic and immunological differences. The antigen handling and processing at the maternal-fetal interface during pregnancy appear to be crucial for the adaptation of the maternal immune system and for tolerance to the developing fetus and placenta. Maternal antigen-presenting cells (APCs), such as macrophages (Mφs) and dendritic cells (DCs), are present at the maternal-fetal interface throughout pregnancy and are believed to play a crucial role in this process. Despite numerous studies focusing on the significance of Mφs, there is limited knowledge regarding the contribution of DCs in fetomaternal tolerance during pregnancy, making it a relatively new and growing field of research. This review focuses on how the behavior of DCs at the maternal-fetal interface adapts to pregnancy's unique demands. Moreover, it discusses how DCs interact with other cells in the decidual leukocyte network to regulate uterine and placental homeostasis and the local maternal immune responses to the fetus. The review particularly examines the different cell lineages of DCs with specific surface markers, which have not been critically reviewed in previous publications. Additionally, it emphasizes the impact that even minor disruptions in DC functions can have on pregnancy-related complications and proposes further research into the potential therapeutic benefits of targeting DCs to manage these complications.

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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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