完全胰腺切除术患者和健康个体对体外催产素的糖代谢反应。

IF 2.8 4区 医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Peptides Pub Date : 2024-05-22 DOI:10.1016/j.peptides.2024.171242
Vivian Kliim-Hansen , Ida M. Gether , Caroline T.-B. Juel , Anne-Marie Ellegaard , Miriam G. Pedersen , Bolette Hartmann , Nicolai J. Wewer Albrechtsen , Jens J. Holst , Asger B. Lund , Lærke S. Gasbjerg , Filip K. Knop
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引用次数: 0

摘要

催产素被认为可通过从胰腺释放胰岛素和胰高血糖素来起到稳定血糖的作用。此外,外源性催产素还能刺激去势犬胰腺外胰高血糖素的分泌。在此,我们研究了外源性催产素对循环中胰腺和肠道来源的葡萄糖稳定激素(胰岛素 [以 C 肽衡量]、胰高血糖素、胰高血糖素样肽 1 [GLP-1] 和葡萄糖依赖性促胰岛素多肽)水平的影响。我们研究了九名胰腺切除术(PX)患者和九名健康对照组(CTRLs)(年龄和体重指数相匹配)在 12 分钟内静脉注射 10 IU 催产素之前、期间和之后的情况。催产素不会增加血浆胰高血糖素水平,也不会引起血浆葡萄糖、C 肽或 GIP 的任何变化。催产素使 CTRL 患者的血浆胰高血糖素水平降低了 19 ± 10%(从 2.0 ± 0.5 [mean ± SEM] 降至 1.3 ± 0.2 pmol/l,P = 0.0025),使 PX 患者的 GLP-1 水平升高了 42 ± 22%(从 9.0 ± 1.0 升至 12.7 ± 1.0 pmol/l,P = 0.0003)。与 CTRLs 相比,PX 患者的空腹血浆葡萄糖水平更高(13.1 ± 1.1 vs. 5.1 ± 0.1mmol/l,P < 0.0001)。总之,目前的研究结果并不支持人体急性注射催产素后胰腺介导的葡萄糖稳定作用,因此有必要进一步研究催产素的葡萄糖代谢作用。试验注册 ClinicalTrials.gov NCT02944110。
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Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals

Oxytocin has been proposed to possess glucose-stabilizing effects through the release of insulin and glucagon from the pancreas. Also, exogenous oxytocin has been shown to stimulate extrapancreatic glucagon secretion in depancreatized dogs. Here, we investigated the effect of exogenous oxytocin on circulating levels of pancreatic and gut-derived glucose-stabilizing hormones (insulin [measured as C-peptide], glucagon, glucagon-like peptide 1 [GLP-1], and glucose-dependent insulinotropic polypeptide). We studied nine pancreatectomized (PX) patients and nine healthy controls (CTRLs) (matched on age and body mass index) before, during, and after an intravenous infusion of 10 IU of oxytocin administered over 12 min. Oxytocin did not increase plasma glucagon levels, nor induce any changes in plasma glucose, C-peptide, or GIP in any of the groups. Oxytocin decreased plasma glucagon levels by 19 ± 10 % in CTRLs (from 2.0 ± 0.5 [mean ± SEM] to 1.3 ± 0.2 pmol/l, P = 0.0025) and increased GLP-1 by 42 ± 22 % in PX patients (from 9.0 ± 1.0–12.7 ± 1.0 pmol/l, P = 0.0003). Fasting plasma glucose levels were higher in PX patients compared with CTRLs (13.1 ± 1.1 vs. 5.1 ± 0.1 mmol/l, P < 0.0001). In conclusion, the present findings do not support pancreas-mediated glucose-stabilizing effects of acute oxytocin administration in humans and warrant further investigation of oxytocin’s gluco-metabolic effects.

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来源期刊
Peptides
Peptides 医学-生化与分子生物学
CiteScore
6.40
自引率
6.70%
发文量
130
审稿时长
28 days
期刊介绍: Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.
期刊最新文献
The Viktor Mutt Award Lecture 2024 to Thomas Hökfelt. The effects of corticotropin-releasing factor (CRF) and urocortins on the noradrenaline (NA) released from the locus coeruleus (LC). Corrigendum to "Lasso peptides realm: Insights and applications" Peptides 182(December) (2024) 171317. Host defense peptides at the crossroad of endothelial cell physiology: Insight into mechanistic and pharmacological implications Discovery of the bioactive form of glucagon-like peptide-1: An attempt to correct some misconceptions
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