[霍奇金淋巴瘤治疗的现行标准]。

Deutsche medizinische Wochenschrift (1946) Pub Date : 2024-06-01 Epub Date: 2024-05-23 DOI:10.1055/a-2203-0454
Johannes C Hellmuth
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引用次数: 0

摘要

这篇综述讨论了霍奇金淋巴瘤治疗的当前趋势,重点是优化治疗效果,同时尽量减少毒性。我们总结了将 Brentuximab Vedotin 纳入晚期霍奇金淋巴瘤一线疗法所取得的进展。同样,将检查点抑制纳入一线疗法也大有可为,早期结果表明其疗效显著,毒性降低。对于复发或难治性霍奇金淋巴瘤,挽救性化疗后进行大剂量化疗和自体干细胞移植仍是标准方法。然而,检查点抑制剂在这种情况下的显著疗效有可能重新定义治疗范式,使特定患者不再需要进行HD-ASCT。最后,我们讨论了结节性淋巴细胞占优势的霍奇金淋巴瘤不断演变的情况,以及随着人们对其独特特征和治疗策略的认识不断提高,结节性淋巴细胞占优势的B细胞淋巴瘤被重新分类为结节性淋巴细胞占优势的B细胞淋巴瘤。
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[Current Standards in the Treatment of Hodgkin Lymphoma].

This review discusses current trends in the treatment of Hodgkin lymphoma, focusing on optimizing therapy outcomes while minimizing toxicity. We summarize advances made by the incorporation of Brentuximab Vedotin into first line therapy for advanced stage Hodgkin lymphoma. Similarly, the incorporation of checkpoint-inhibition into first-line therapy holds great promise and early results suggest superior efficacy with reduced toxicity. In relapsed or refractory Hodgkin lymphoma, salvage chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation remains the standard approach. However, the remarkable efficacy of checkpoint inhibition in this setting has the potential to redefine treatment paradigms and obviate the need for HD-ASCT in select patients. Finally, we discuss the evolving landscape of nodular lymphocyte predominant Hodgkin lymphoma and reclassification to nodular lymphocyte predominant B-cell lymphoma, with increasing recognition of its distinct characteristics and treatment strategies.

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