L(1)10Bb通过睾丸干细胞龛内的细胞非自主效应,成为体细胞与胚系沟通的保守决定因素

IF 3.8 3区 医学 Q2 CELL BIOLOGY Molecular and Cellular Endocrinology Pub Date : 2024-05-23 DOI:10.1016/j.mce.2024.112278
Lei He , Feiteng Sun , Yunhao Wu , Zhiran Li , Yangbo Fu, Qiuru Huang, Jiaxin Li, Zihan Wang, Jiaying Cai, Chenrui Feng, Xiaonan Deng, Han Gu, Xuxin He, Jun Yu, Fei Sun
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引用次数: 0

摘要

睾丸干细胞龛是黑腹果蝇精子发生的核心调节因子。然而,其潜在的调控机制尚不清楚。本研究证明了致死(1)10Bb [l(1)10Bb] 在调节睾丸干细胞龛中的关键作用。早期囊肿细胞中的l(1)10Bb功能失调会导致男性生育障碍,并影响囊肿干细胞的维持。此外,早期囊肿细胞中l(1)10Bb的功能障碍对生殖系干细胞分化产生非自主性影响,与中枢信号无关。值得注意的是,我们的研究强调了通过异位表达L(1)10Bb和人类同源蛋白BUD31同源物(BUD31)来挽救睾丸缺陷。此外,l(1)10Bb在早期囊肿细胞中的功能障碍下调了Sm和前体RNA加工复合物中剪接体亚基的表达。总之,我们的研究结果确定了l(1)10Bb是果蝇睾丸干细胞龛内调节体细胞与胚系沟通的关键因素。
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L(1)10Bb serves as a conservative determinant for soma-germline communications via cellular non-autonomous effects within the testicular stem cell niche

The testicular stem cell niche is the central regulator of spermatogenesis in Drosophila melanogaster. However, the underlying regulatory mechanisms are unclear. This study demonstrated the crucial role of lethal (1) 10Bb [l(1)10Bb] in regulating the testicular stem cell niche. Dysfunction of l(1)10Bb in early-stage cyst cells led to male fertility disorders and compromised cyst stem cell maintenance. Moreover, the dysfunction of l(1)10Bb in early-stage cyst cells exerted non-autonomous effects on germline stem cell differentiation, independently of hub signals. Notably, our study highlights the rescue of testicular defects through ectopic expression of L(1)10Bb and the human homologous protein BUD31 homolog (BUD31). In addition, l(1)10Bb dysfunction in early-stage cyst cells downregulated the expression of spliceosome subunits in the Sm and the precursor RNA processing complexes. Collectively, our findings established l(1)10Bb as a pivotal factor in the modulation of Drosophila soma-germline communications within the testicular stem cell niche.

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来源期刊
Molecular and Cellular Endocrinology
Molecular and Cellular Endocrinology 医学-内分泌学与代谢
CiteScore
9.00
自引率
2.40%
发文量
174
审稿时长
42 days
期刊介绍: Molecular and Cellular Endocrinology was established in 1974 to meet the demand for integrated publication on all aspects related to the genetic and biochemical effects, synthesis and secretions of extracellular signals (hormones, neurotransmitters, etc.) and to the understanding of cellular regulatory mechanisms involved in hormonal control.
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