离散潜隐嵌入揭示单细胞表观组学中的细胞多样性

IF 12 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS Nature computational science Pub Date : 2024-05-24 DOI:10.1038/s43588-024-00634-3
Zhi Wei
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引用次数: 0

摘要

CASTLE 是一种深度学习方法,可从单细胞染色质可及性数据中提取可解释的离散表示,从而实现准确的细胞类型鉴定、有效的数据整合以及对基因调控机制的定量洞察。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Discrete latent embeddings illuminate cellular diversity in single-cell epigenomics
CASTLE, a deep learning approach, extracts interpretable discrete representations from single-cell chromatin accessibility data, enabling accurate cell type identification, effective data integration, and quantitative insights into gene regulatory mechanisms.
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