F. Khan, V. Yogendrakumar, R. Lun, A. Ganesh, V. Lioutas, N. Vinding, A. Algra, C. Weimar, J. Ögren, J Edwards, R. Swartz, A. Ois, E. Giralt-Steinhauer, H. Bae, M. Kamouchi, F. de Leeuw, J. Verhoeven, T. Uehara, K. Minematsu, S. Fandler-Höfler, M. Foschi, W. Whiteley, F. Purroy, J. Jing, Y. Wang, M. Baik, Y Kim, M. Spampinato, F. Ildstad, Y. Hasegawa, K. Perera, H. Park, D. Dutta, P. Barber, S. Coutts, M. Hill
{"title":"B.6 短暂性脑缺血发作或轻微脑卒中后继发脑卒中的长期风险:系统回顾和荟萃分析","authors":"F. Khan, V. Yogendrakumar, R. Lun, A. Ganesh, V. Lioutas, N. Vinding, A. Algra, C. Weimar, J. Ögren, J Edwards, R. Swartz, A. Ois, E. Giralt-Steinhauer, H. Bae, M. Kamouchi, F. de Leeuw, J. Verhoeven, T. Uehara, K. Minematsu, S. Fandler-Höfler, M. Foschi, W. Whiteley, F. Purroy, J. Jing, Y. Wang, M. Baik, Y Kim, M. Spampinato, F. Ildstad, Y. Hasegawa, K. Perera, H. Park, D. Dutta, P. Barber, S. Coutts, M. Hill","doi":"10.1017/cjn.2024.85","DOIUrl":null,"url":null,"abstract":"Background: After a transient ischemic attack (TIA) or minor stroke, the long-term risk of subsequent stroke is uncertain. Methods: Electronic databases were searched for observational studies reporting subsequent stroke during a minimum follow-up of 1 year in patients with TIA or minor stroke. Unpublished data on number of stroke events and exact person-time at risk contributed by all patients during discrete time intervals of follow-up were requested from the authors of included studies. This information was used to calculate the incidence of stroke in individual studies, and results across studies were pooled using random-effects meta-analysis. Results: Fifteen independent cohorts involving 129794 patients were included in the analysis. The pooled incidence rate of subsequent stroke per 100 person-years was 6.4 events in the first year and 2.0 events in the second through tenth years, with cumulative incidences of 14% at 5 years and 21% at 10 years. Based on 10 studies with information available on fatal stroke, the pooled case fatality rate of subsequent stroke was 9.5% (95% CI, 5.9 – 13.8). Conclusions: One in five patients is expected to experience a subsequent stroke within 10 years after a TIA or minor stroke, with every tenth patient expected to die from their subsequent stroke.","PeriodicalId":9571,"journal":{"name":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","volume":"11 8","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"B.6 Long-term risk of subsequent stroke after transient ischemic attack or minor stroke: a systematic review and meta-analysis\",\"authors\":\"F. Khan, V. Yogendrakumar, R. Lun, A. Ganesh, V. Lioutas, N. Vinding, A. Algra, C. Weimar, J. Ögren, J Edwards, R. Swartz, A. Ois, E. Giralt-Steinhauer, H. Bae, M. Kamouchi, F. de Leeuw, J. Verhoeven, T. Uehara, K. Minematsu, S. Fandler-Höfler, M. Foschi, W. Whiteley, F. Purroy, J. Jing, Y. Wang, M. Baik, Y Kim, M. Spampinato, F. Ildstad, Y. Hasegawa, K. Perera, H. Park, D. Dutta, P. Barber, S. Coutts, M. Hill\",\"doi\":\"10.1017/cjn.2024.85\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: After a transient ischemic attack (TIA) or minor stroke, the long-term risk of subsequent stroke is uncertain. Methods: Electronic databases were searched for observational studies reporting subsequent stroke during a minimum follow-up of 1 year in patients with TIA or minor stroke. Unpublished data on number of stroke events and exact person-time at risk contributed by all patients during discrete time intervals of follow-up were requested from the authors of included studies. This information was used to calculate the incidence of stroke in individual studies, and results across studies were pooled using random-effects meta-analysis. Results: Fifteen independent cohorts involving 129794 patients were included in the analysis. The pooled incidence rate of subsequent stroke per 100 person-years was 6.4 events in the first year and 2.0 events in the second through tenth years, with cumulative incidences of 14% at 5 years and 21% at 10 years. Based on 10 studies with information available on fatal stroke, the pooled case fatality rate of subsequent stroke was 9.5% (95% CI, 5.9 – 13.8). Conclusions: One in five patients is expected to experience a subsequent stroke within 10 years after a TIA or minor stroke, with every tenth patient expected to die from their subsequent stroke.\",\"PeriodicalId\":9571,\"journal\":{\"name\":\"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques\",\"volume\":\"11 8\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1017/cjn.2024.85\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1017/cjn.2024.85","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
B.6 Long-term risk of subsequent stroke after transient ischemic attack or minor stroke: a systematic review and meta-analysis
Background: After a transient ischemic attack (TIA) or minor stroke, the long-term risk of subsequent stroke is uncertain. Methods: Electronic databases were searched for observational studies reporting subsequent stroke during a minimum follow-up of 1 year in patients with TIA or minor stroke. Unpublished data on number of stroke events and exact person-time at risk contributed by all patients during discrete time intervals of follow-up were requested from the authors of included studies. This information was used to calculate the incidence of stroke in individual studies, and results across studies were pooled using random-effects meta-analysis. Results: Fifteen independent cohorts involving 129794 patients were included in the analysis. The pooled incidence rate of subsequent stroke per 100 person-years was 6.4 events in the first year and 2.0 events in the second through tenth years, with cumulative incidences of 14% at 5 years and 21% at 10 years. Based on 10 studies with information available on fatal stroke, the pooled case fatality rate of subsequent stroke was 9.5% (95% CI, 5.9 – 13.8). Conclusions: One in five patients is expected to experience a subsequent stroke within 10 years after a TIA or minor stroke, with every tenth patient expected to die from their subsequent stroke.