P.001 从 ERP 的角度看强迫症(OCD)的规划与决策:比较分析

D. Kar, S. Tarafder, N. Goyal
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引用次数: 0

摘要

研究背景本研究旨在调查强迫症患者与对照组相比,冲动性对规划和决策的影响,重点是伦敦塔(TOL)任务中的振幅和潜伏期。研究方法共有 76 人(优势右手,年龄在 18-30 岁之间)参与了这项研究。强迫症患者通过Y-BOCS和症状检查表、BIS-11进行评估,强迫症患者通过GHQ-12进行筛查。ERP成分通过E-prime 3.0上的TOL进行测量。对每个问题解决任务的振幅、潜伏期和频谱功率进行了测量和分析。结果:在大脑左前额区的潜伏期变量中发现了统计学上的显著差异,表明强迫症患者与对照组相比具有独特的潜伏期模式。其他运动序列的振幅或潜伏期在统计学上未发现明显差异。强迫症患者的频谱活动持续时间较长。结论:强迫症患者在决策过程中表现出较高的矛盾活动,这表明为了克服冲动,他们需要付出更多的认知努力来维持相同的结果。为了保持无误的结果,强迫症和强迫行为是必要之恶。
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P.001 Planning & decision-making in obsessive-compulsive disorder (OCD) through the lens of ERP: a comparative analysis
Background: This study aimed to investigate the effect of impulsivity on the planning & decision-making of individuals with OCD compared to a control group, focusing on amplitude and latency during the Tower of London (TOL) task. Methods: A sample of a total of 76 (dominantly right-handed & aged between 18-30 yrs) participated. Participants with OCD were assessed with the Y-BOCS & symptom checklist, BIS-11, and the HCs were screened with the GHQ-12. ERP components were measured by using TOL on E-prime 3.0. The amplitude and latency along with the spectral power for each problem-solving task were measured and analyzed. Results: Statistically significant differences were found in the Latency variable in the left frontal area of the brain, indicating distinctive latency patterns in individuals with OCD compared to controls. No statistically significant differences were observed in amplitude or latency for other move sequences. High spectral activity was detected in individuals with OCD for an extended period. Conclusions: Individuals with OCD exhibit higher activity indicative of ambivalence during decision-making which indicates that to overcome impulsive urges, thus they need to put more cognitive effort to maintain the same outcomes. To maintain error-free results obsessive & compulsive behaviors are a necessary evil.
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