冠状动脉搭桥手术后早期无声冠状动脉搭桥移植物闭塞,常规冠状动脉计算机断层扫描血管造影的意义

Islam Salikhanov, Luca Koechlin, Brigitta Gahl, Oliver Reuthebuch, Michael Zellweger, Philip Haaf, Jens Bremerich, Maurice Pradella, Christian Müller, Denis Berdajs
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摘要

利用心脏计算机断层扫描血管造影术评估冠状动脉搭桥手术后早期无声旁路闭塞的发生率和预测因素。共有 439 名连续患者接受了孤立冠状动脉搭桥手术,出院前进行了 CT 扫描,患者平均年龄为 66±10 岁,其中女性占 17%(n = 75)。对1319个吻合口的移植物通畅性进行了评估,其中44%(n = 580)进行了动脉吻合,56%(n = 739)进行了静脉移植物吻合。我们对心血管风险因素、人口统计学和术中变量进行了分析。我们进行了单变量和多变量逻辑回归分析,以分析与 CABG 术后移植物闭塞可能相关的变量。变量包括性别、手术时间、移植物血流、搏动指数、静脉移植物与动脉移植物以及近期心肌梗死。移植物闭塞的总发生率为 2.4%(31/1319),6.6% 的患者(29/439)确诊为闭塞。动脉(2.1%)和静脉(2.6%)移植物闭塞的差异不显著,P = 0.68。闭塞组的介入时间 p = 0.034、交叉钳夹时间 p = 0.024 以及远端吻合次数 p = 0.034 均明显高于闭塞组。单变量和多变量逻辑回归结果显示,手术时间是旁路移植闭塞的预测因素,OR = 1.18;95% CI:1.01-1.38;p = 0.035。远端吻合的数量和手术干预的持续时间对发生 EGO 的风险有显著影响。反映复杂冠状动脉病理的手术时间延长和耗时的血管重建过程也与闭塞风险升高有关。
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Early silent coronary bypass graft occlusion following coronary bypass surgery, implication of routine coronary computed tomography angiography
To evaluate incidence and predictors of early silent bypass occlusion following coronary bypass surgery using cardiac computed tomography angiography.A total of 439 consecutive patients with mean age of 66 ± 10 years comprising 17% (n = 75) females underwent isolated coronary bypass surgery followed by CT scan before discharge. Graft patency was evaluated in 1,319 anastomoses where 44% (n = 580) arterial and 56% (n = 739) vein graft anastomosis were performed. Cardiovascular risk factors, demographics, and intraoperative variables were analyzed. We conducted univariable and multivariable logistic regression analyses to analyze variables potentially associated with graft occlusion following CABG. Variables included gender, surgery duration, graft flow, pulsatility index, vein vs. artery graft, and recent MI.Overall incidence of graft occlusion was 2.4% (31/1,319), and it was diagnosed in 6.6% (29/439) of patients. The difference in occlusion between arterial (2.1%) and vein (2.6%) grafts was not significant, p = 0.68. The duration of intervention p = 0.034, cross clamp time p = 0.024 as well the number of distal anastomosis p = 0.034 were significantly higher in occlusion group. The univariate and multivariate logistic regression indicated duration of surgery being predictive for bypass graft occlusion with OR = 1.18; 95% CI: 1.01–1.38; p = 0.035.Early graft occlusion was associated with surgical factors. The number of distant anastamoses, along duration of surgical intervention were, significantly influenced the risk of EGO. Prolonged procedural time reflecting complex coronary pathology and time-consuming revascularization procedure was as well associated to the elevated risk of occlusion.
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