导管分流锥形狭窄动脉中血液卡松流体流动的生物结构研究:在药物输送中的应用

IF 2.3 4区 工程技术 Q2 INSTRUMENTS & INSTRUMENTATION Microfluidics and Nanofluidics Pub Date : 2024-05-21 DOI:10.1007/s10404-024-02735-x
Noreen Sher Akbar, Maimona Rafiq, Taseer Muhammad, Metib Alghamdi
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引用次数: 0

摘要

目前的研究重点是利用一个血流模型,研究磁力和不同形状的纳米粒子对患有狭窄的分叉锥形动脉的影响。本研究的一个显著特点是在水基流体介质中探索各种形状的金属纳米粒子,而这一研究领域在很大程度上仍未被开发。为了模拟血流动力学,我们采用了径向对称但轴向非对称的狭窄配置,从而深入了解了病变动脉内复杂的流动模式。我们研究的一个重要贡献在于分析了管壁剪应力的对称分布及其与阻抗的相关性。此外,我们还研究了这些量随狭窄严重程度而逐渐增加的情况。通过数值模拟,我们评估了多个流动参数,包括速度、温度、阻抗、边界剪应力和狭窄喉部的剪应力。通过这些评估,我们可以全面了解纳米粒子形状和磁力对锥形动脉内血流特征的多方面影响。此外,我们的研究还探索了铜血液系统相关参数范围内各种流动量的图形表示方法。通过研究不同类型的锥形动脉,特别是发散锥形配置,我们深入了解了动脉几何形状、流体流变学和纳米粒子行为之间错综复杂的相互作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Biological structural study for the blood casson fluid flow in catheterized diverging tapered stenosed arteries with emerging shaped nanoparticles: application in drug delivery

The current research focuses on investigating the influence of magnetic forces and differently shaped nanoparticles within diverging tapering arteries afflicted with stenoses, utilizing a blood flow model. A notable aspect of this study is the exploration of metallic nanoparticles of various shapes within a water-based fluid medium, a research area that remains largely unexplored. To simulate blood flow dynamics, a radially symmetric yet axially non-symmetric stenosis configuration is employed, providing insights into the complex flow patterns within diseased arteries. A significant contribution of our research lies in the analysis of the symmetrical distribution of wall shearing stresses and their correlation with resistive impedance. Moreover, we investigate the progressive rise of these quantities in tandem with stenosis severity. Through numerical simulations, we evaluate several flow parameters, including velocity, temperature, resistance impedance, boundary shear stress, and shearing stress at the stenosis throat. These assessments provide a comprehensive understanding of the multifaceted effects of nanoparticle shape and magnetic forces on blood flow characteristics within tapered arteries. Furthermore, our study explores the graphical representation of various flow quantities across a spectrum of relevant parameters for Cu-blood systems. By examining different types of tapered arteries, particularly diverging tapering configurations, we gain insights into the intricate interplay between arterial geometry, fluid rheology, and nanoparticle behavior.

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来源期刊
Microfluidics and Nanofluidics
Microfluidics and Nanofluidics 工程技术-纳米科技
CiteScore
4.80
自引率
3.60%
发文量
97
审稿时长
2 months
期刊介绍: Microfluidics and Nanofluidics is an international peer-reviewed journal that aims to publish papers in all aspects of microfluidics, nanofluidics and lab-on-a-chip science and technology. The objectives of the journal are to (1) provide an overview of the current state of the research and development in microfluidics, nanofluidics and lab-on-a-chip devices, (2) improve the fundamental understanding of microfluidic and nanofluidic phenomena, and (3) discuss applications of microfluidics, nanofluidics and lab-on-a-chip devices. Topics covered in this journal include: 1.000 Fundamental principles of micro- and nanoscale phenomena like, flow, mass transport and reactions 3.000 Theoretical models and numerical simulation with experimental and/or analytical proof 4.000 Novel measurement & characterization technologies 5.000 Devices (actuators and sensors) 6.000 New unit-operations for dedicated microfluidic platforms 7.000 Lab-on-a-Chip applications 8.000 Microfabrication technologies and materials Please note, Microfluidics and Nanofluidics does not publish manuscripts studying pure microscale heat transfer since there are many journals that cover this field of research (Journal of Heat Transfer, Journal of Heat and Mass Transfer, Journal of Heat and Fluid Flow, etc.).
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