D. Binjawhar, A. S. Alqahtani, Ola A Abu Ali, Eman Fayad, Fawziah A Al-Salmi, I. M. El-Deen, Mohamed Ahmed Elian Sophy
{"title":"开发具有强效抗乳腺癌活性的新型 N-和 S-取代咪唑烷-4-酮类似物:体外分子对接评估","authors":"D. Binjawhar, A. S. Alqahtani, Ola A Abu Ali, Eman Fayad, Fawziah A Al-Salmi, I. M. El-Deen, Mohamed Ahmed Elian Sophy","doi":"10.2174/0113852728298899240402083333","DOIUrl":null,"url":null,"abstract":"\n\n2-Thioxoimidazolidin-4-one derivatives 3, 4, 7, 8, and 9 have been synthesized from 3-\n(benzylideneamino)-2-thioxoimidazolidin-4-one (2) as a starting material. Compounds 3, 4, 7, 8, and 9 were\nobtained via the reaction of compound (2) with ethyl chloroacetate, methyl acrylate, and chlorophenacyl bromide,\nrespectively. Elemental analysis and several spectroscopy techniques were used to confirm the synthesized\ncompounds. The synthesized compounds, particularly compounds 7 and 8, exhibited significant cytotoxic\ninfluences on MCF-7 cells, surpassing staurosporine. Compounds 7 and 8 can induce apoptosis in those treated\nMCF-7 cells. Studying molecular docking approved that compounds 7 and 8 bind in two and three dimensions\nto the aromatase binding pockets. Molecular modeling indicates compounds 7 and 8 have a strong affinity for\nhuman topoisomerase II beta, establishing its promise as a multifaceted antitumor agent for breast cancer.\n\n\n\nNew N- and S- Substituted-Imidazolidin-4-one\n","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of New N- and S-Substituted-Imidazolidin-4-one Analogues with Potent Anti-Breast Cancer Activity: In vitro Molecular Docking Assessment\",\"authors\":\"D. Binjawhar, A. S. Alqahtani, Ola A Abu Ali, Eman Fayad, Fawziah A Al-Salmi, I. M. El-Deen, Mohamed Ahmed Elian Sophy\",\"doi\":\"10.2174/0113852728298899240402083333\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\n2-Thioxoimidazolidin-4-one derivatives 3, 4, 7, 8, and 9 have been synthesized from 3-\\n(benzylideneamino)-2-thioxoimidazolidin-4-one (2) as a starting material. Compounds 3, 4, 7, 8, and 9 were\\nobtained via the reaction of compound (2) with ethyl chloroacetate, methyl acrylate, and chlorophenacyl bromide,\\nrespectively. Elemental analysis and several spectroscopy techniques were used to confirm the synthesized\\ncompounds. The synthesized compounds, particularly compounds 7 and 8, exhibited significant cytotoxic\\ninfluences on MCF-7 cells, surpassing staurosporine. Compounds 7 and 8 can induce apoptosis in those treated\\nMCF-7 cells. Studying molecular docking approved that compounds 7 and 8 bind in two and three dimensions\\nto the aromatase binding pockets. Molecular modeling indicates compounds 7 and 8 have a strong affinity for\\nhuman topoisomerase II beta, establishing its promise as a multifaceted antitumor agent for breast cancer.\\n\\n\\n\\nNew N- and S- Substituted-Imidazolidin-4-one\\n\",\"PeriodicalId\":10926,\"journal\":{\"name\":\"Current Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0113852728298899240402083333\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728298899240402083333","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Development of New N- and S-Substituted-Imidazolidin-4-one Analogues with Potent Anti-Breast Cancer Activity: In vitro Molecular Docking Assessment
2-Thioxoimidazolidin-4-one derivatives 3, 4, 7, 8, and 9 have been synthesized from 3-
(benzylideneamino)-2-thioxoimidazolidin-4-one (2) as a starting material. Compounds 3, 4, 7, 8, and 9 were
obtained via the reaction of compound (2) with ethyl chloroacetate, methyl acrylate, and chlorophenacyl bromide,
respectively. Elemental analysis and several spectroscopy techniques were used to confirm the synthesized
compounds. The synthesized compounds, particularly compounds 7 and 8, exhibited significant cytotoxic
influences on MCF-7 cells, surpassing staurosporine. Compounds 7 and 8 can induce apoptosis in those treated
MCF-7 cells. Studying molecular docking approved that compounds 7 and 8 bind in two and three dimensions
to the aromatase binding pockets. Molecular modeling indicates compounds 7 and 8 have a strong affinity for
human topoisomerase II beta, establishing its promise as a multifaceted antitumor agent for breast cancer.
New N- and S- Substituted-Imidazolidin-4-one
期刊介绍:
Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.