Yasmen Osama, E. Abdel‐Latif, H. Metwally, Ali El-Rayyes, T. Khatab
{"title":"将氧化锌 NPs 作为一种新催化剂用于合成咪唑并[2,1-b]喹唑啉衍生物并将其作为极光激酶 (AKI-001) 抑制剂进行 Docking 验证的绿色合成方法","authors":"Yasmen Osama, E. Abdel‐Latif, H. Metwally, Ali El-Rayyes, T. Khatab","doi":"10.2174/0113852728309261240507065414","DOIUrl":null,"url":null,"abstract":"\n\nAs natural capping reagents, flaxseed gel, caprylic/capric triglyceride, aloe vera,\nand propylene glycol were utilized in the synthesis of ZnO-NPs in the current study. The\nsynthesized ZnO NPs structure was characterized by Transmission Electron Microscopy\n(TEM), Fourier Transform Infrared (FT-IR), and X-Ray Diffraction (XRD). The prepared\nZnO-NPs were used as an efficient catalyst for the production of a new series of fused polynuclear\nheterocyclic system-based imidazoquinazoline by multicomponent reaction. The\nreaction was initiated by mixing 2-aminobenzimidazole, aryl/hetaryl aldehydes, and betanaphthol\nunder solvent-free conditions at 60-70 °C in the presence of a catalytic amount of\nthe synthesized ZnO-NPs. As demonstrated by molecular docking, the prepared ligands (4,\n7, 8, 9, and 11) exhibited outstanding validation as aurora kinase inhibitors in comparison to\nAKI-001, the prototype pentacyclic inhibitor.\n\n\n\nsynthesis of some new imidazo[2,1-b]quinazoline derivatives by green method with docking validation as aurora kinase (AKI-001) inhibitor\n\n\n\nno\n","PeriodicalId":10926,"journal":{"name":"Current Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Green Synthesis of Zinc Oxide NPs as a New Catalyst for the Synthesis of Imidazo[2,1-b]quinazoline Derivatives with Docking Validation as Aurora Kinase (AKI-001) Inhibitors\",\"authors\":\"Yasmen Osama, E. Abdel‐Latif, H. Metwally, Ali El-Rayyes, T. Khatab\",\"doi\":\"10.2174/0113852728309261240507065414\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n\\nAs natural capping reagents, flaxseed gel, caprylic/capric triglyceride, aloe vera,\\nand propylene glycol were utilized in the synthesis of ZnO-NPs in the current study. The\\nsynthesized ZnO NPs structure was characterized by Transmission Electron Microscopy\\n(TEM), Fourier Transform Infrared (FT-IR), and X-Ray Diffraction (XRD). The prepared\\nZnO-NPs were used as an efficient catalyst for the production of a new series of fused polynuclear\\nheterocyclic system-based imidazoquinazoline by multicomponent reaction. The\\nreaction was initiated by mixing 2-aminobenzimidazole, aryl/hetaryl aldehydes, and betanaphthol\\nunder solvent-free conditions at 60-70 °C in the presence of a catalytic amount of\\nthe synthesized ZnO-NPs. As demonstrated by molecular docking, the prepared ligands (4,\\n7, 8, 9, and 11) exhibited outstanding validation as aurora kinase inhibitors in comparison to\\nAKI-001, the prototype pentacyclic inhibitor.\\n\\n\\n\\nsynthesis of some new imidazo[2,1-b]quinazoline derivatives by green method with docking validation as aurora kinase (AKI-001) inhibitor\\n\\n\\n\\nno\\n\",\"PeriodicalId\":10926,\"journal\":{\"name\":\"Current Organic Chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Organic Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.2174/0113852728309261240507065414\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0113852728309261240507065414","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Green Synthesis of Zinc Oxide NPs as a New Catalyst for the Synthesis of Imidazo[2,1-b]quinazoline Derivatives with Docking Validation as Aurora Kinase (AKI-001) Inhibitors
As natural capping reagents, flaxseed gel, caprylic/capric triglyceride, aloe vera,
and propylene glycol were utilized in the synthesis of ZnO-NPs in the current study. The
synthesized ZnO NPs structure was characterized by Transmission Electron Microscopy
(TEM), Fourier Transform Infrared (FT-IR), and X-Ray Diffraction (XRD). The prepared
ZnO-NPs were used as an efficient catalyst for the production of a new series of fused polynuclear
heterocyclic system-based imidazoquinazoline by multicomponent reaction. The
reaction was initiated by mixing 2-aminobenzimidazole, aryl/hetaryl aldehydes, and betanaphthol
under solvent-free conditions at 60-70 °C in the presence of a catalytic amount of
the synthesized ZnO-NPs. As demonstrated by molecular docking, the prepared ligands (4,
7, 8, 9, and 11) exhibited outstanding validation as aurora kinase inhibitors in comparison to
AKI-001, the prototype pentacyclic inhibitor.
synthesis of some new imidazo[2,1-b]quinazoline derivatives by green method with docking validation as aurora kinase (AKI-001) inhibitor
no
期刊介绍:
Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.