与 K48 和 K63 链接的泛素链相互作用组揭示了分支和长度特异性泛素相互作用因子

IF 3.3 2区 生物学 Q1 BIOLOGY Life Science Alliance Pub Date : 2024-05-21 DOI:10.26508/lsa.202402740
Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Phillip Mertins, Thomas Sommer
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引用次数: 0

摘要

泛素相互作用因子下拉与质谱联用技术阐明了 K48 和 K63 连接的相互作用组,包括新型异型分支和链长特异性结合体。这一筛选为我们了解如何读取复杂的 Ub 结构奠定了基础。
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K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors
Ubiquitin interactor pulldown coupled with mass spectrometry elucidates K48- and K63-linked interactomes including novel heterotypic branch- and chain length–specific binders. This screen lays the foundations for our understanding of how complex Ub architectures are read.
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来源期刊
Life Science Alliance
Life Science Alliance Agricultural and Biological Sciences-Plant Science
CiteScore
5.80
自引率
2.30%
发文量
241
审稿时长
10 weeks
期刊介绍: Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.
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