H PASHA, AT Tariq, A BANGASH, M. Salim, T MOHIUDIN
{"title":"接受直接作用抗病毒药物治疗的慢性病毒性肝炎患者清除 Hcv 后代谢和肾脏系统的变化","authors":"H PASHA, AT Tariq, A BANGASH, M. Salim, T MOHIUDIN","doi":"10.54112/bcsrj.v2024i1.837","DOIUrl":null,"url":null,"abstract":"Chronic hepatitis C infection is associated with metabolic and renal abnormalities, with direct antiviral agents (DAAs) offering a promising treatment approach. However, the influence of hepatitis C virus (HCV) clearance on metabolic and renal parameters in these patients remains underexplored. Objective: This study aimed to assess the impact of HCV clearance on the metabolic and renal system of chronic hepatitis C patients treated with direct antiviral agents. Methods: A prospective study was conducted at the Department of Medicine, Shifa Hospital, Islamabad, from January 2022 to January 2024. A total of 323 patients with chronic hepatitis C treated with DAAs were included. Hepatic and renal function tests were recorded before treatment, post-treatment, and 6-month follow-up. Insulin resistance (IR) and B-cell function were evaluated using the homeostatic model assessment (HOMA). All patients received DAAs treatment, with or without ribavirin. Statistical analysis was performed using appropriate methods. Results: Following HCV clearance, both groups exhibited a significant decrease in fasting glucose and insulin levels and improvements in HOMA-IR values. Additionally, decreased creatinine levels and increased glomerular filtration rate (GFR) indicated enhanced renal function. Sustained virologic response (SVR) emerged as an independent predictor of improvement in GFR and HOMA-IR. Conclusion: HCV clearance in chronic hepatitis C infection, achieved through treatment with direct antiviral agents, leads to notable improvements in renal and metabolic parameters. These findings underscore the importance of achieving SVR in managing chronic hepatitis C.","PeriodicalId":9008,"journal":{"name":"Biological and Clinical Sciences Research Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CHANGES IN METABOLIC AND RENAL SYSTEM AFTER HCV CLEARANCE IN CHRONIC VIRAL HEPATITIS PATIENTS TREATED WITH DIRECT-ACTING ANTIVIRALS\",\"authors\":\"H PASHA, AT Tariq, A BANGASH, M. Salim, T MOHIUDIN\",\"doi\":\"10.54112/bcsrj.v2024i1.837\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chronic hepatitis C infection is associated with metabolic and renal abnormalities, with direct antiviral agents (DAAs) offering a promising treatment approach. However, the influence of hepatitis C virus (HCV) clearance on metabolic and renal parameters in these patients remains underexplored. Objective: This study aimed to assess the impact of HCV clearance on the metabolic and renal system of chronic hepatitis C patients treated with direct antiviral agents. Methods: A prospective study was conducted at the Department of Medicine, Shifa Hospital, Islamabad, from January 2022 to January 2024. A total of 323 patients with chronic hepatitis C treated with DAAs were included. Hepatic and renal function tests were recorded before treatment, post-treatment, and 6-month follow-up. Insulin resistance (IR) and B-cell function were evaluated using the homeostatic model assessment (HOMA). All patients received DAAs treatment, with or without ribavirin. Statistical analysis was performed using appropriate methods. Results: Following HCV clearance, both groups exhibited a significant decrease in fasting glucose and insulin levels and improvements in HOMA-IR values. Additionally, decreased creatinine levels and increased glomerular filtration rate (GFR) indicated enhanced renal function. Sustained virologic response (SVR) emerged as an independent predictor of improvement in GFR and HOMA-IR. Conclusion: HCV clearance in chronic hepatitis C infection, achieved through treatment with direct antiviral agents, leads to notable improvements in renal and metabolic parameters. These findings underscore the importance of achieving SVR in managing chronic hepatitis C.\",\"PeriodicalId\":9008,\"journal\":{\"name\":\"Biological and Clinical Sciences Research Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological and Clinical Sciences Research Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54112/bcsrj.v2024i1.837\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological and Clinical Sciences Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54112/bcsrj.v2024i1.837","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
CHANGES IN METABOLIC AND RENAL SYSTEM AFTER HCV CLEARANCE IN CHRONIC VIRAL HEPATITIS PATIENTS TREATED WITH DIRECT-ACTING ANTIVIRALS
Chronic hepatitis C infection is associated with metabolic and renal abnormalities, with direct antiviral agents (DAAs) offering a promising treatment approach. However, the influence of hepatitis C virus (HCV) clearance on metabolic and renal parameters in these patients remains underexplored. Objective: This study aimed to assess the impact of HCV clearance on the metabolic and renal system of chronic hepatitis C patients treated with direct antiviral agents. Methods: A prospective study was conducted at the Department of Medicine, Shifa Hospital, Islamabad, from January 2022 to January 2024. A total of 323 patients with chronic hepatitis C treated with DAAs were included. Hepatic and renal function tests were recorded before treatment, post-treatment, and 6-month follow-up. Insulin resistance (IR) and B-cell function were evaluated using the homeostatic model assessment (HOMA). All patients received DAAs treatment, with or without ribavirin. Statistical analysis was performed using appropriate methods. Results: Following HCV clearance, both groups exhibited a significant decrease in fasting glucose and insulin levels and improvements in HOMA-IR values. Additionally, decreased creatinine levels and increased glomerular filtration rate (GFR) indicated enhanced renal function. Sustained virologic response (SVR) emerged as an independent predictor of improvement in GFR and HOMA-IR. Conclusion: HCV clearance in chronic hepatitis C infection, achieved through treatment with direct antiviral agents, leads to notable improvements in renal and metabolic parameters. These findings underscore the importance of achieving SVR in managing chronic hepatitis C.