Jesslyn Park, Hetvee Desai, José Liboy-Lugo, Sohyun Gu, Ziad M. Jowhar, Albert Xu, S. Floor
{"title":"IGHMBP2 基因缺失会抑制翻译并激活综合应激反应","authors":"Jesslyn Park, Hetvee Desai, José Liboy-Lugo, Sohyun Gu, Ziad M. Jowhar, Albert Xu, S. Floor","doi":"10.26508/lsa.202302554","DOIUrl":null,"url":null,"abstract":"We characterized the genetic consequences of deleting IGHMBP2—a disease-relevant perturbation—in human cells. IGHMBP2-dependent gene expression changes included up-regulation of ATF4, a key ISR factor.","PeriodicalId":18081,"journal":{"name":"Life Science Alliance","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"IGHMBP2 deletion suppresses translation and activates the integrated stress response\",\"authors\":\"Jesslyn Park, Hetvee Desai, José Liboy-Lugo, Sohyun Gu, Ziad M. Jowhar, Albert Xu, S. Floor\",\"doi\":\"10.26508/lsa.202302554\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We characterized the genetic consequences of deleting IGHMBP2—a disease-relevant perturbation—in human cells. IGHMBP2-dependent gene expression changes included up-regulation of ATF4, a key ISR factor.\",\"PeriodicalId\":18081,\"journal\":{\"name\":\"Life Science Alliance\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2024-05-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life Science Alliance\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.26508/lsa.202302554\",\"RegionNum\":2,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life Science Alliance","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.26508/lsa.202302554","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOLOGY","Score":null,"Total":0}
IGHMBP2 deletion suppresses translation and activates the integrated stress response
We characterized the genetic consequences of deleting IGHMBP2—a disease-relevant perturbation—in human cells. IGHMBP2-dependent gene expression changes included up-regulation of ATF4, a key ISR factor.
期刊介绍：
Life Science Alliance is a global, open-access, editorially independent, and peer-reviewed journal launched by an alliance of EMBO Press, Rockefeller University Press, and Cold Spring Harbor Laboratory Press. Life Science Alliance is committed to rapid, fair, and transparent publication of valuable research from across all areas in the life sciences.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
