心力衰竭预后预测 :让我们从 MDL-HFP 模型开始

IF 3 2区 计算机科学 Q2 COMPUTER SCIENCE, INFORMATION SYSTEMS Information Systems Pub Date : 2024-05-21 DOI:10.1016/j.is.2024.102408
Huiting Ma , Dengao Li , Jian Fu , Guiji Zhao , Jumin Zhao
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引用次数: 0

摘要

心力衰竭是各种心脏病的重要症状或终末阶段,是世界级的公共卫生问题。建立预后模型有助于识别高危患者,及时挽救他们的生命,减轻医疗负担。虽然将结构化指标和非结构化文本进行信息互补已被证明在疾病预测任务中行之有效,但仍存在一定的局限性。首先,单一分支模式的处理容易被忽视,从而影响最终的融合结果。其次,简单的融合会丢失模态间的互补信息,限制网络的学习能力。第三,不完整的可解释性会影响模型的实际应用和发展。为了克服这些难题,本文提出了利用 MIMIC-III 公共数据库预测患者预后的 MDL-HFP 多模态模型。首先,使用 ADASYN 算法处理数据类别的不平衡。然后,利用改进的 Deep&Cross 网络进行自动特征选择,对结构稀疏的特征进行编码,并在 HR-BGCN 模型的基础上引入隐式图结构信息,对非结构化的临床笔记进行编码。最后,通过跨模态动态交互层融合两种模态的信息。通过比较多个先进的多模态深度学习模型,验证了该模型的有效性,其平均 F1 得分为 90.42%,平均准确率为 90.70%。本文提出的模型可以准确地对患者的再入院状态进行分类,从而帮助医生做出判断,改善患者的预后。进一步的可视化分析表明了模型的可用性,为临床决策提供了全面的解释。
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Heart failure prognosis prediction: Let’s start with the MDL-HFP model

Heart failure, as a critical symptom or terminal stage of assorted heart diseases, is a world-class public health problem. Establishing a prognostic model can help identify high dangerous patients, save their lives promptly, and reduce medical burden. Although integrating structured indicators and unstructured text for complementary information has been proven effective in disease prediction tasks, there are still certain limitations. Firstly, the processing of single branch modes is easily overlooked, which can affect the final fusion result. Secondly, simple fusion will lose complementary information between modalities, limiting the network’s learning ability. Thirdly, incomplete interpretability can affect the practical application and development of the model. To overcome these challenges, this paper proposes the MDL-HFP multimodal model for predicting patient prognosis using the MIMIC-III public database. Firstly, the ADASYN algorithm is used to handle the imbalance of data categories. Then, the proposed improved Deep&Cross Network is used for automatic feature selection to encode structured sparse features, and implicit graph structure information is introduced to encode unstructured clinical notes based on the HR-BGCN model. Finally, the information of the two modalities is fused through a cross-modal dynamic interaction layer. By comparing multiple advanced multimodal deep learning models, the model’s effectiveness is verified, with an average F1 score of 90.42% and an average accuracy of 90.70%. The model proposed in this paper can accurately classify the readmission status of patients, thereby assisting doctors in making judgments and improving the patient’s prognosis. Further visual analysis demonstrates the usability of the model, providing a comprehensive explanation for clinical decision-making.

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来源期刊
Information Systems
Information Systems 工程技术-计算机:信息系统
CiteScore
9.40
自引率
2.70%
发文量
112
审稿时长
53 days
期刊介绍: Information systems are the software and hardware systems that support data-intensive applications. The journal Information Systems publishes articles concerning the design and implementation of languages, data models, process models, algorithms, software and hardware for information systems. Subject areas include data management issues as presented in the principal international database conferences (e.g., ACM SIGMOD/PODS, VLDB, ICDE and ICDT/EDBT) as well as data-related issues from the fields of data mining/machine learning, information retrieval coordinated with structured data, internet and cloud data management, business process management, web semantics, visual and audio information systems, scientific computing, and data science. Implementation papers having to do with massively parallel data management, fault tolerance in practice, and special purpose hardware for data-intensive systems are also welcome. Manuscripts from application domains, such as urban informatics, social and natural science, and Internet of Things, are also welcome. All papers should highlight innovative solutions to data management problems such as new data models, performance enhancements, and show how those innovations contribute to the goals of the application.
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