{"title":"研究夹竹桃叶纳米提取物对雄性实验鼠肝脏组织结构的影响","authors":"Saja Hassan Abd Al-Kadhim, Jabbar Abadi Mohammed","doi":"10.31559/vmph2024.5.2.12","DOIUrl":null,"url":null,"abstract":"Objectives: The purpose of the research was to see how a nano-extract (zinc oxide) of oleander leaves affected the histological structure of the liver in male laboratory mice aged (7-8) weeks and weighing (28-35 g). Methods: They were split up into three groups, with ten mice in each. The control group made the first group. The second group was treated with an oleander leaf nano-extract at a concentration of (20 mg/kg). The group that was administered a 30 mg/kg dosage of oleander leaf nano-extract is the third group. For 30 to 45 days on a daily basis, a (30 mg/kg) concentration of the oleander leaf nano-extract was used. Half of the rodents were sacrificed at the end of the initial thirty days, and histological sections of the liver were obtained. Results: Histological sections of the liver were obtained from the residual half, which was sacrificed after 45 days when the experiment ended. Animals injected with a Nano-extract of oleander leaves at a dose of (20 mg/kg) for 40 days had aberrant liver structure, cells, and histological abnormalities. Animals that received a 45-day injection of a (30 mg/kg) dosage of oleander leaf nano-extract also had pathological alterations and aberrant liver and central vein cell morphology. Conclusions: The results showed the toxic effects of the Nano-extract of the oleander plant and the xistence of histological alterations in the histological structure of the liver in groups treated with varying amounts of oleander leaf nano-extract.","PeriodicalId":385877,"journal":{"name":"Veterinary Medicine and Public Health Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Studying the Effect of nano-extract of Nerium Oleander Leaves on the Histological Structure of the Liver in Male Laboratory Mice\",\"authors\":\"Saja Hassan Abd Al-Kadhim, Jabbar Abadi Mohammed\",\"doi\":\"10.31559/vmph2024.5.2.12\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: The purpose of the research was to see how a nano-extract (zinc oxide) of oleander leaves affected the histological structure of the liver in male laboratory mice aged (7-8) weeks and weighing (28-35 g). Methods: They were split up into three groups, with ten mice in each. The control group made the first group. The second group was treated with an oleander leaf nano-extract at a concentration of (20 mg/kg). The group that was administered a 30 mg/kg dosage of oleander leaf nano-extract is the third group. For 30 to 45 days on a daily basis, a (30 mg/kg) concentration of the oleander leaf nano-extract was used. Half of the rodents were sacrificed at the end of the initial thirty days, and histological sections of the liver were obtained. Results: Histological sections of the liver were obtained from the residual half, which was sacrificed after 45 days when the experiment ended. Animals injected with a Nano-extract of oleander leaves at a dose of (20 mg/kg) for 40 days had aberrant liver structure, cells, and histological abnormalities. Animals that received a 45-day injection of a (30 mg/kg) dosage of oleander leaf nano-extract also had pathological alterations and aberrant liver and central vein cell morphology. Conclusions: The results showed the toxic effects of the Nano-extract of the oleander plant and the xistence of histological alterations in the histological structure of the liver in groups treated with varying amounts of oleander leaf nano-extract.\",\"PeriodicalId\":385877,\"journal\":{\"name\":\"Veterinary Medicine and Public Health Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-05-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Medicine and Public Health Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.31559/vmph2024.5.2.12\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Medicine and Public Health Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31559/vmph2024.5.2.12","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Studying the Effect of nano-extract of Nerium Oleander Leaves on the Histological Structure of the Liver in Male Laboratory Mice
Objectives: The purpose of the research was to see how a nano-extract (zinc oxide) of oleander leaves affected the histological structure of the liver in male laboratory mice aged (7-8) weeks and weighing (28-35 g). Methods: They were split up into three groups, with ten mice in each. The control group made the first group. The second group was treated with an oleander leaf nano-extract at a concentration of (20 mg/kg). The group that was administered a 30 mg/kg dosage of oleander leaf nano-extract is the third group. For 30 to 45 days on a daily basis, a (30 mg/kg) concentration of the oleander leaf nano-extract was used. Half of the rodents were sacrificed at the end of the initial thirty days, and histological sections of the liver were obtained. Results: Histological sections of the liver were obtained from the residual half, which was sacrificed after 45 days when the experiment ended. Animals injected with a Nano-extract of oleander leaves at a dose of (20 mg/kg) for 40 days had aberrant liver structure, cells, and histological abnormalities. Animals that received a 45-day injection of a (30 mg/kg) dosage of oleander leaf nano-extract also had pathological alterations and aberrant liver and central vein cell morphology. Conclusions: The results showed the toxic effects of the Nano-extract of the oleander plant and the xistence of histological alterations in the histological structure of the liver in groups treated with varying amounts of oleander leaf nano-extract.