Occurrence of legacy and Emerging per- and polyfluoroalkyl substances (PFASs) in indoor dust from office environment in south china

Per- and polyfluoroalkyl substances (PFASs) constitute a broad group of fluorinated organic chemicals that are widely used in consumer products and industrial applications due to their excellent physicochemical properties. Given that people spend a significant portion of their time in office environments, our understanding of the environmental presence and human exposure to these chemicals is crucial. In this study, we conducted a targeted analysis of 24 PFASs in office indoor environments. The ΣPFAS concentrations ranged from 51.6 to 219 ng/g with mean (±SE) and median concentrations of 114 (±5.75) and 107 ng/g, respectively. Hexafluoropropylene oxide dimer acid (HFPO-DA) was the most abundant emerging PFAS detected in the dust, with mean and median concentrations of 40.5 (±1.62) and 40.4 ng/g, respectively, comprising 34.2 % of the ΣPFAS concentrations. Notably, HFPO-DA exhibited a positive correlation with perfluorooctane sulfonate (PFOS) (r: 0.427, p < 0.01), suggesting a potential common source for these two compounds. Our findings underscore the significant contribution of emerging PFASs to total PFAS concentrations and raise concerns about their chronic toxicity and potential health risks to humans in office indoor environments.