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引用次数: 0
摘要
导言：本研究的目的是通过静息态功能连接（FC）和心率变异性（HRV）评估血糖与自律神经系统（ANS）功能之间的关系。方法：本研究的数据取自莱比锡心-体-动互动研究（Leipzig Study for Mind-Body-Emotion Interactions），其中包括 146 名健康成年人（114 名年轻人，32 名老年人）。研究变量包括糖化血红蛋白（HbA1c）、中枢-自主神经（S-CAN）和显著性网络（SN）显著性方面的静息态 FC 以及心率变异（RMSSD 和高频心率变异（HF-HRV））。HbA1c 与心率变异成反比。在 S-CAN 和 SN 中，RMSSD 和 log(HF-HRV) 均与 FC 相关。在 Hb1Ac-FC 关联中观察到年龄差异（与性别无关）（在老年人中更明显），而在 HRV-FC 中观察到性别差异（与年龄无关）（在女性中更明显）。这些关系中与年龄和性别相关的差异突出表明，在未来的研究中需要考虑年龄和性别的潜在影响。
The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences
Introduction
The purpose of this study was to clarify the relationships between glycemia and function of the autonomic nervous system (ANS), assessed via resting-state functional connectivity (FC) and heart-rate variability (HRV).
Methods
Data for this study were extracted from the Leipzig Study for Mind-Body-Emotion Interactions, including 146 healthy adults (114 young, 32 older). Variables of interest were glycated hemoglobin (HbA1c), resting-state FC in the salience aspect of the central-autonomic (S-CAN) and salience network (SN) and HRV (RMSSD and high-frequency HRV (HF-HRV)).
Results
HbA1c was inversely correlated with FC in the S-CAN but not SN. HbA1c was inversely correlated with HRV. Both RMSSD and log(HF-HRV) were correlated with FC in the S-CAN and SN. Age- (not sex-related) differences were observed in the Hb1Ac-FC associations (stronger in older adults) while sex- (not age-related) differences were observed in the HRV-FC (stronger in females).
Conclusions
These findings extend the diabetes literature to healthy adults in relating glycemia and brain function. The age- and sex-related differences in these relationships highlight the need to account for the potential effects of age and sex in future investigations.
期刊介绍：
Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.
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